Other drugs

Question 1

Expectorants

Answer 1

Guaifenesin: thins respiratory secretion, does not suppress cough reflex

N-acetylcysteine: mucolytic; loosen mucous plugs in CF

Question 2

Bosentan

Answer 2

Used to treat pulm arterial HTN.

Competitively antagonizes endothelin 1 receptor, decreasing pulm vascular resistance.

Question 3

Dextromethorphan

Answer 3

Antitussive (antagonizes NMDA glutamate receptor)
Synthetic codeine analog.
Mild opioid effect when used in excess.
Naloxone for overdose
Mild abuse potential

Question 4

Pseudoephedrine, phenylephrine

Answer 4

Sympathomimetic alpha agonist
Reduces hyperemia, edema, and nasal congestion;
Open obstructed eustachian tubes.
Pseudoephedrine also used as a stimulant

Toxicity: HTN, CNS stimulation/anxiety (pseudoephedrine)

Can’t be used for more than 2 days, tachyphylaxis.

Question 5

Methacholine

Answer 5

Muscarinic receptor agonist.

Used in asthma challenge testing.