CO2 transport

Question 1

CO2 transported by three forms

Answer 1

1) bicarb (90%)
2) carbaminohemoglobin of HbCO2 (5%) at N terminus (this binding favors taut form, O2 unloaded)
3) dissolved (5%)

Question 2

In lungs, oxygenation of Hb, what effect

Answer 2

Promotes dissociation of H+ from Hb
Shifts equilibrium toward CO2 formation

Thus, CO2 is released from RBC (Haldane effect)

Question 3

In peripheral tissue, what effect

Answer 3

Increased H+ from tissue metabolism
shifts curve to right, unloading O2

This is called Bohr effect