Oxygen and Carbon dioxide transport

Question 1

How is O2 transported around the body?

Answer 1

1. 5% dissolved in plasma (0.3ml/dL)

98. 5% bound to haemoglobin (19.7ml/dL)

Question 2

What is Methaemoglobin?

Answer 2

Fe3+ haemoglobin which cannot carry O2

Presents as brown blood with extreme cyanosis

Question 3

What effect does pH have on O2 affinity?

Answer 3

High = greater affinity
Low = lesser affinity

Question 4

What O2 sats require O2 to be administered?

Answer 4

<92%

Question 5

How is CO2 transported around the body?

Answer 5

9% dissolved in plasma
13% as Carbaminohaemoglobin
78% as CHO3-

Question 6

What is Anaemia?

Answer 6

a state where the Hb level is below normal

Question 7

What are some common haemoglobinopathies?

Answer 7

Mutations leading to methaemoglobinaemia
Spontaneous denaturation of Hb
Mutations to Hb causing lower affinity of O2
Reduced water solubility mutations