Oxazolidinonas Flashcards

1
Q

mecanismo de accion oxazolidinonas

A

inhiben la sintesis de proteinas uniendose a la subunidad ribosomal 50s, igual que la Clindamicina

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2
Q

oxazolidinonas bactericidad o bacteriostaticos

A

bacteriostaticos

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3
Q

mencione 2 oxazolidinonas

A

linezolid

tedizolid

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4
Q

via de adm oxazolidinonas

A

ev

vo

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5
Q

via de eliminacion oxazolidinonas

A

hepatica (60%) y renal

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6
Q

gram positivos que cubre oxazolidinonas

A

estreptococo
MRSA
VRE

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7
Q

cubren anaerobios las oxazolidinonas? si su respuesta es si, diga cuales

A

si, como el clostridium difficile, peptoestreptococo

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8
Q

que mycobacterias cubren las oxazolidinonas

A

mycobacterias de crecimiento rapido

mycobacterium tuberculosis

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9
Q

efectos adversos oxazolidinonas

A

sindrome serotoninergico
mielosupresion (mas comunmente trombocitopenia, neutropenia y anemia)
neuritis optica
hiperpigmentacion lingual

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10
Q

que es el sindrome serotoninergico y por que atb es causado

A

consiste en una inhibicion de la serotonina y de la MAO, lo hacen las oxazolidinonas, y producen en el px vasodilatacion, diarrea, enrojecimiento y alergia

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11
Q

farmaco de las oxazolidinonas mas asociado a neuritis optica

A

linezolid

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12
Q

oxazolidinonas categoria en el embarazo

A

C, pero se usan en px pediatricos

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13
Q

oxazolidinonas atraviesan la bhe

A

no

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14
Q

contraindicaciones oxazolidinonas

A

meningitis
endocarditis
ivu

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15
Q

indicaciones oxazolidinonas

A
neumonia y NAV
infecciones piel y tejido blando
osteomielitis
2da linea TB
enfermedades provocadas por cocos gram + que no sean severas
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16
Q

por VO, cuanto se absorbe el linezolid

A

100%

17
Q

oxazolidinona asociada a menos sindrome serotininergico y se adm 1 vez al dia

A

tedizolid

18
Q

oxazolidinonas pueden usarse en px pediatricos

A

si

19
Q

cuales son los unicos bactericidas que inhiben la sintesis proteica

A

aminoglucosidos

20
Q

para el tx de una tuberculosis, el linezolid y las quinolonas que linea de tx es

A

2da linea

21
Q

pregunta random: que uso si una pseudomona es resistente a meropenem?

A

polimixina o colistina