Ovarian Cancer

Question 1

risk factors for ovarian cancer

Answer 1

increased age
early menarch, late menopause
nulliparity (no kids)
in-vitro fertilization
2+ first degree relatives

Question 2

genetic risks for ovarian cancer

Answer 2

BRCA 1/2
HNPCC

Question 3

what decreases risk ovarian cancer

Answer 3

multiple pregnancies
prolonged use oral contraceptives
oopherectomy

Question 4

symptoms of ovarian cancer

Answer 4

like period symptoms

Question 5

what is considered optimally debulked

Answer 5

<1 cm left

Question 6

what is considered sub-optimally debulked

Answer 6

> 1 cm left of disease

Question 7

type I hypersensitivity

Answer 7

immediately upon exposure
anaphylaxis, itching, rash

Question 8

type IV hypersensitivity

Answer 8

repeated over time with extensive exposure
erythema

Question 9

which drugs cause hypersensitivity reactions

Answer 9

platinums and taxanes

Question 10

what is a true allergic reaction

Answer 10

will not stop after stopping the infusion
hives, itching, SOB, swelling

Question 11

what is an infusion related reaction

Answer 11

flushing
redness
tingling
symptoms stop after stopping infusion

Question 12

paclitaxel reaction usuallly what type

Answer 12

type I

Question 13

what would we give before pacliaxel infusion

Answer 13

dexamethasone
diphenhydramine
famotidine

Question 14

what would we give before docetaxel

Answer 14

dexamethasone

Question 15

what would we give before Nab-paclixtaxel

Answer 15

nothing, we dont get those reactions

Question 16

what type of hypersensitivity for carboplatin

Answer 16

type IV

Question 17

when does carboplatin hypersensitivy start

Answer 17

8 cycles

Question 18

can we give paclitaxel if we get a hypersensitivty reaction

Answer 18

yes, small dilutions

Question 19

maintenance therapy if BRCA mutation

Answer 19

PARP inhibitors

Question 20

maintenance therapy if no BRCA

Answer 20

bevacizumab

Question 21

PARP inhibitor side effect

Answer 21

anemia

Question 22

what is platinum sensitive

Answer 22

> 6 months after chemo relapse, initial regimen again

Question 23

what is platinum resistant

Answer 23

< 6 month after chemo relapse

Question 24

what is platinum progressive

Answer 24

they never responded to initial chem

Question 25

if platinum sensitive what do we give in ovarian

Answer 25

carboplatin and paclitaxel

Question 26

what is used for platinum resistant ovarian cancer

Answer 26

liposomal doxorubicin

Question 27

screening for ovarian cancer

Answer 27

no good screening
if high risk: pelvic exam and transvaginal ultrasound

Question 28

prevention of ovarian cancer

Answer 28

oral contraceptives > 5 years
prophylactic oopherectomy