Ovarian Cancer Flashcards
risk factors for ovarian cancer
increased age
early menarch, late menopause
nulliparity (no kids)
in-vitro fertilization
2+ first degree relatives
genetic risks for ovarian cancer
BRCA 1/2
HNPCC
what decreases risk ovarian cancer
multiple pregnancies
prolonged use oral contraceptives
oopherectomy
symptoms of ovarian cancer
like period symptoms
what is considered optimally debulked
<1 cm left
what is considered sub-optimally debulked
> 1 cm left of disease
type I hypersensitivity
immediately upon exposure
anaphylaxis, itching, rash
type IV hypersensitivity
repeated over time with extensive exposure
erythema
which drugs cause hypersensitivity reactions
platinums and taxanes
what is a true allergic reaction
will not stop after stopping the infusion
hives, itching, SOB, swelling
what is an infusion related reaction
flushing
redness
tingling
symptoms stop after stopping infusion
paclitaxel reaction usuallly what type
type I
what would we give before pacliaxel infusion
dexamethasone
diphenhydramine
famotidine
what would we give before docetaxel
dexamethasone
what would we give before Nab-paclixtaxel
nothing, we dont get those reactions
what type of hypersensitivity for carboplatin
type IV
when does carboplatin hypersensitivy start
8 cycles
can we give paclitaxel if we get a hypersensitivty reaction
yes, small dilutions
maintenance therapy if BRCA mutation
PARP inhibitors
maintenance therapy if no BRCA
bevacizumab
PARP inhibitor side effect
anemia
what is platinum sensitive
> 6 months after chemo relapse, initial regimen again
what is platinum resistant
< 6 month after chemo relapse
what is platinum progressive
they never responded to initial chem
if platinum sensitive what do we give in ovarian
carboplatin and paclitaxel
what is used for platinum resistant ovarian cancer
liposomal doxorubicin
screening for ovarian cancer
no good screening
if high risk: pelvic exam and transvaginal ultrasound
prevention of ovarian cancer
oral contraceptives > 5 years
prophylactic oopherectomy
