Addnl Agents

Question 1

DNA methylation inhibitor

Answer 1

azacitibine

Question 2

how does a DNA methylatioin inhibitor work

Answer 2

covalently binds DNMT enzymes and prevents functiion, incorporates into DNA

Question 3

azacitibine indication

Answer 3

myelodysplastic syndrome (MDS)
ALL with venetoclax

Question 4

what disease state is a good target for proteasome inhibitors

Answer 4

multiple myeloma

Question 5

proteasome inhibitior

Answer 5

bortezomib

Question 6

bortezomib target and disease state

Answer 6

multiple myeloma
proteasome inhibitor

Question 7

pomalidomide indication

Answer 7

multiple myeloma and Kaposi sarcoma

Question 8

pomalidomide does waht

Answer 8

blocks CRBN to degrade transcription factors

Question 9

PROTACS do what

Answer 9

degrade a target

Question 10

what is BCL-2

Answer 10

anti -apoptosis protein

Question 11

what inhibits BCL-2

Answer 11

venetoclax

Question 12

venetoclax does what

Answer 12

inhibits BCL-2 to drive apoptosis

Question 13

what drug is first fda approved for protein-protein interaction

Answer 13

venetoclax

Question 14

what is used in combo with azacitidine for ALL

Answer 14

venetoclax