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PHRM 864 > Immuneotherapy > Flashcards

Immuneotherapy Flashcards

1
Q

first immunotherapy drug

A

Coley’s Toxin

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2
Q

what would happen if we used a mouse antibody in human

A

body will clear it via the immune system

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3
Q

what do B cells produce

A

antibodies

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4
Q

-omab

A

mouse antibody

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5
Q

-iximab

A

chimeric antibody

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6
Q

-zumab

A

humanized

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7
Q

-umab

A

fully human

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8
Q

explain the two tiered effect of antibodies

A

binding of antibodies to receptor on surface of cancer cells can lead to CDC or ADCC complement or antibody dependent cytotoxicity
inhibit receptor and kill cell

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9
Q

what is trastuzumab class

A

humanized mab

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10
Q

trastuzumab target

A

HER2

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11
Q

trastuzumab increased risk of cardiomyopathy with what drug

A

adriamycin

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12
Q

how does trastuzumab work?

A

antibody dependent cytotoxicity

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13
Q

pertuzumab used in combo with what

A

trastuzumab

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14
Q

pertuzumab does what

A

binds HER2 receptor and prevents dimerization

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15
Q

what drugs were in CLEOPATRA trial?

A

trastuzumab
pertuzumab

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16
Q

cetuximab binds what

A

EGFR extracellular domain

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17
Q

what does cetuximab do (3)

A

blocks phosphorylation of kinases
inhibits cell growth and induces apoptosis
comp inhibits binding of EGF

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18
Q

cetuximab indications

A

colorectal cancer
head / neck cancer

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19
Q

cetuximab side effects

A

rash

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20
Q

EGFR inhibitors have what side effect?

A

rash, means better prognosis

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21
Q

what is panitumumab

A

like cetuximab but without the infusion toxicity

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22
Q

bevacizumab target

A

VEGF

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23
Q

bevacizumab does what

A

binds VEGF ligand and blocks int with endothelial receptors
blocks endothelial cell prolif and new blood vessel form
inhibits solid tumor growth

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24
Q

bevacizumab used with what

A

5-FU

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25
Q

what binds VEGF ligand

A

bevicizumab

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26
Q

what binds VEGF receptor

A

ramucirumab

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27
Q

what works with B cells receptor to drive proliferation of B cells

28
Q

what is CD20 expressed by?

A

normal B lymphocytes
immature pre-B cells

29
Q

what disease state is CD20 expressed on B cells

A

non-Hodgkins lymphoma

30
Q

what is rituximab target

31
Q

what is rituximab for

A

B cell lymphoma (non-Hodgkins lymphoma)

32
Q

what does daratumumab target

33
Q

what does daratumumab treat

A

multiple myeloma

34
Q

CD38 expressed on what cells

A

plasma cells
(multiple myeloma)

35
Q

what drugs are in T-DM1

A

emtansine and trastuzumab

36
Q

what is emtansine

A

cytotoxic microtubule assembly inhibitor

37
Q

T-DM1use

A

HER2 + breast cancer, second line

38
Q

how is the purpose of using T-DM1 combo

A

reduced toxicity side effects

39
Q

CD3 is on what type of cells

40
Q

side effect from immunotherapies

A

cytokine storm, massive infection

41
Q

blinatumomab targets and treats what

A

CD3 t cell
CD19 B cell
ALL

42
Q

mosunetuzumab target and treats what

A

CD3 T cell
CD20 B cell
non hodgkin lymphoma

43
Q

teclistamab target and treats

A

CD3
BCMA
multiple myeloma

44
Q

taquetamab target and treats

A

CD3
GPRC5D
multiple myeloma

45
Q

Bite drugs

A

blinatumomab
mosunetuzumab
teclistamab
taquetamab

46
Q

ALL antigen

47
Q

MM antigens

A

BCMA
CD38
GPRC5D

48
Q

non hodgkin lymphoma antigens

49
Q

ipilmumab target

A

CTLA-4 receptor

50
Q

ipilumumab treats what

A

metastatic melanoma

51
Q

ipilumab side effectg

A

sever immune response

52
Q

what drug targets CTLA-4

A

ipilumumab

53
Q

what drug targets PD-1

A

pembrolizumab
(Keytruda)

54
Q

what does pembrolizumab target

55
Q

PD-1 is where

56
Q

PDL-1 is where

A

macrophages and tumor cells

57
Q

pembrolizumab indications

A

advanced metastatic melanoma following ipilumab and a BRAF inhibitor
NSCLC if PDL-1 positive

58
Q

pembrolizumab can be used in NSCLC if what

A

PD-L1 positive

59
Q

pembrolizumab can be used in metastatic melanoma if what

A

tried treatment with Ipilmumab and if BRAFV600 mutation a BRAF inhibitor

60
Q

which drug targets PD-L1

A

atezolizumab

61
Q

what does atelizumab target

62
Q

what is cell therapy

A

take antigen presenting cells out of pt
activate with drug ex vivo
put back in pt
want to stimulate pts own immune system to attack the cancer

63
Q

what is the cell therapy drug

A

sipulcel T

64
Q

what is sipulcel-T indicated for

A

minimally symptomatic metastatic hormome refractory prostate cancer

65
Q

what is the common target of CART therapy

PHRM 864 (28 decks)

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