Immuneotherapy Flashcards
first immunotherapy drug
Coley’s Toxin
what would happen if we used a mouse antibody in human
body will clear it via the immune system
what do B cells produce
antibodies
-omab
mouse antibody
-iximab
chimeric antibody
-zumab
humanized
-umab
fully human
explain the two tiered effect of antibodies
binding of antibodies to receptor on surface of cancer cells can lead to CDC or ADCC complement or antibody dependent cytotoxicity
inhibit receptor and kill cell
what is trastuzumab class
humanized mab
trastuzumab target
HER2
trastuzumab increased risk of cardiomyopathy with what drug
adriamycin
how does trastuzumab work?
antibody dependent cytotoxicity
pertuzumab used in combo with what
trastuzumab
pertuzumab does what
binds HER2 receptor and prevents dimerization
what drugs were in CLEOPATRA trial?
trastuzumab
pertuzumab
cetuximab binds what
EGFR extracellular domain
what does cetuximab do (3)
blocks phosphorylation of kinases
inhibits cell growth and induces apoptosis
comp inhibits binding of EGF
cetuximab indications
colorectal cancer
head / neck cancer
cetuximab side effects
rash
EGFR inhibitors have what side effect?
rash, means better prognosis
what is panitumumab
like cetuximab but without the infusion toxicity
bevacizumab target
VEGF
bevacizumab does what
binds VEGF ligand and blocks int with endothelial receptors
blocks endothelial cell prolif and new blood vessel form
inhibits solid tumor growth
bevacizumab used with what
5-FU
what binds VEGF ligand
bevicizumab
what binds VEGF receptor
ramucirumab