Immuneotherapy

Question 1

first immunotherapy drug

Answer 1

Coley’s Toxin

Question 2

what would happen if we used a mouse antibody in human

Answer 2

body will clear it via the immune system

Question 3

what do B cells produce

Answer 3

antibodies

Question 4

-omab

Answer 4

mouse antibody

Question 5

-iximab

Answer 5

chimeric antibody

Question 6

-zumab

Answer 6

humanized

Question 7

-umab

Answer 7

fully human

Question 8

explain the two tiered effect of antibodies

Answer 8

binding of antibodies to receptor on surface of cancer cells can lead to CDC or ADCC complement or antibody dependent cytotoxicity
inhibit receptor and kill cell

Question 9

what is trastuzumab class

Answer 9

humanized mab

Question 10

trastuzumab target

Answer 10

HER2

Question 11

trastuzumab increased risk of cardiomyopathy with what drug

Answer 11

adriamycin

Question 12

how does trastuzumab work?

Answer 12

antibody dependent cytotoxicity

Question 13

pertuzumab used in combo with what

Answer 13

trastuzumab

Question 14

pertuzumab does what

Answer 14

binds HER2 receptor and prevents dimerization

Question 15

what drugs were in CLEOPATRA trial?

Answer 15

trastuzumab
pertuzumab

Question 16

cetuximab binds what

Answer 16

EGFR extracellular domain

Question 17

what does cetuximab do (3)

Answer 17

blocks phosphorylation of kinases
inhibits cell growth and induces apoptosis
comp inhibits binding of EGF

Question 18

cetuximab indications

Answer 18

colorectal cancer
head / neck cancer

Question 19

cetuximab side effects

Answer 19

rash

Question 20

EGFR inhibitors have what side effect?

Answer 20

rash, means better prognosis

Question 21

what is panitumumab

Answer 21

like cetuximab but without the infusion toxicity

Question 22

bevacizumab target

Answer 22

VEGF

Question 23

bevacizumab does what

Answer 23

binds VEGF ligand and blocks int with endothelial receptors
blocks endothelial cell prolif and new blood vessel form
inhibits solid tumor growth

Question 24

bevacizumab used with what

Answer 24

5-FU

Question 25

what binds VEGF ligand

Answer 25

bevicizumab

Question 26

what binds VEGF receptor

Answer 26

ramucirumab

Question 27

what works with B cells receptor to drive proliferation of B cells

Answer 27

CD20

Question 28

what is CD20 expressed by?

Answer 28

normal B lymphocytes immature pre-B cells

Question 29

what disease state is CD20 expressed on B cells

Answer 29

non-Hodgkins lymphoma

Question 30

what is rituximab target

Answer 30

CD20

Question 31

what is rituximab for

Answer 31

B cell lymphoma (non-Hodgkins lymphoma)

Question 32

what does daratumumab target

Answer 32

CD38

Question 33

what does daratumumab treat

Answer 33

multiple myeloma

Question 34

CD38 expressed on what cells

Answer 34

plasma cells (multiple myeloma)

Question 35

what drugs are in T-DM1

Answer 35

emtansine and trastuzumab

Question 36

what is emtansine

Answer 36

cytotoxic microtubule assembly inhibitor

Question 37

T-DM1use

Answer 37

HER2 + breast cancer, second line

Question 38

how is the purpose of using T-DM1 combo

Answer 38

reduced toxicity side effects

Question 39

CD3 is on what type of cells

Answer 39

T cells

Question 40

side effect from immunotherapies

Answer 40

cytokine storm, massive infection

Question 41

blinatumomab targets and treats what

Answer 41

CD3 t cell CD19 B cell ALL

Question 42

mosunetuzumab target and treats what

Answer 42

CD3 T cell CD20 B cell non hodgkin lymphoma

Question 43

teclistamab target and treats

Answer 43

CD3 BCMA multiple myeloma

Question 44

taquetamab target and treats

Answer 44

CD3 GPRC5D multiple myeloma

Question 45

Bite drugs

Answer 45

blinatumomab mosunetuzumab teclistamab taquetamab

Question 46

ALL antigen

Answer 46

CD19

Question 47

MM antigens

Answer 47

BCMA CD38 GPRC5D

Question 48

non hodgkin lymphoma antigens

Answer 48

CD20

Question 49

ipilmumab target

Answer 49

CTLA-4 receptor

Question 50

ipilumumab treats what

Answer 50

metastatic melanoma

Question 51

ipilumab side effectg

Answer 51

sever immune response

Question 52

what drug targets CTLA-4

Answer 52

ipilumumab

Question 53

what drug targets PD-1

Answer 53

pembrolizumab (Keytruda)

Question 54

what does pembrolizumab target

Answer 54

PD-1

Question 55

PD-1 is where

Answer 55

T cells

Question 56

PDL-1 is where

Answer 56

macrophages and tumor cells

Question 57

pembrolizumab indications

Answer 57

advanced metastatic melanoma following ipilumab and a BRAF inhibitor NSCLC if PDL-1 positive

Question 58

pembrolizumab can be used in NSCLC if what

Answer 58

PD-L1 positive

Question 59

pembrolizumab can be used in metastatic melanoma if what

Answer 59

tried treatment with Ipilmumab and if BRAFV600 mutation a BRAF inhibitor

Question 60

which drug targets PD-L1

Answer 60

atezolizumab

Question 61

what does atelizumab target

Answer 61

PD-L1

Question 62

what is cell therapy

Answer 62

take antigen presenting cells out of pt activate with drug ex vivo put back in pt want to stimulate pts own immune system to attack the cancer

Question 63

what is the cell therapy drug

Answer 63

sipulcel T

Question 64

what is sipulcel-T indicated for

Answer 64

minimally symptomatic metastatic hormome refractory prostate cancer

Question 65

what is the common target of CART therapy

Answer 65

CD19