Oncologic Emergencies Flashcards
what is tumor lysis syndrome
metabolic dearangements happening from death of malignant cells
- basically massive release of intracellular contents into bloodstream
what disease states do tumor lysis syndrome occur in
leukemias and lymphomas
tumor lysis syndrome risk factors
older age
renal impairment
drugs (alc, ASA, caffeine, thiazides)
high tumor burden / grade
tumor lysis syndrome effects on electrolytes
hyperkalemia
hyperuricemia
hyperphosphatemia
hypocalcemia
tumor lysis syndrome can cause what
renal failure
tumor lysis syndrome treatment for intermediate risk
hydration
observation
allopurinol
tumor lysis syndrome high risk tx
observation
hydration
rasburicase
difference between allopurinol and rasburicase
rasburicase will decrease the uric acid that is already there
rasburicase considerations
expensive
cant use in pregnant or breast feeding
most emerget emergency
spinal cord compression, could become paralyzed or neurologic dysfunction
most common cancer that causes spinal cord compression
prostate
symptoms of spinal cord compression
pain
motor deficit
sensory deficit
autonomic dysfunction
diagnosis of metastatic spinal cord compression is done how
whole spine MRI
what should be given immediately MSCC
steroids immediately: dexamethasone
radiation - if not surgery
surgery - good performance status
what should be given after surgery / steroids in MSCC
bisphosphonates
