Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PHRM 864 > Breast Cancer > Flashcards

Breast Cancer Flashcards

1
Q

how common is breast cancer death in women compared to other cancers

A
  1. lung
  2. cancer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

are breast cancer cases / deaths going up?

A

no, they have decreased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

do most breast cancer pts have risk factors?

A

no, 60%+ do not have risk factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

risk factors for breast cancer (11)

A

increased age
family history
personal history
radiation
early menarche/late menopause
oral contraceptive / HRT
alcohol
breast biopsies
age >30 first birth
elevated BMI
diet (soy protective)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what percentage of breast cancers are familial

A

5-10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the genes that are linked to breast cancer genetics

A

tumor supressors:
BRCA-1
BRCA-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the GAIL risk model

A

RR% of getting breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

invasive types of breast cancer

A

invasive ductal carcinoma
invasive lobular carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

most common type of breast cancer

A

invasive ductal carcinoma (70%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

non-invasive breast cancer types

A

ductal carcinoma in-situ
lobular carcinoma in-situ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

inflammatory breast cancer description

A

aggressive form with rapid onset and poor prognosis
days and weeks onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

inflammatory breast cancer symptoms

A

edema
redness
warmth
inflammation
orange peel look

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

breast cancer most common presentation

A

90% will have painless lump

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how many will develop metatstatic

A

50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what does FISH testing test for

A

HER2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what tests are for HER2

A

FISH and IHC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is the oncodx

A

determines likelyhood that the cancer will return and if patient would benefit from chemo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what kind of patients can we use oncotype dx on

A

ER+ HER2- newer diagnosis low stage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

low risk wouldnt benefit from chemo score

A

under 26

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

high risk would benefit from chemo score

A

26+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

under 50 but score of what means chemo would be beneficial

A

16-25

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

who mainly gets chemo before surgery

A

Stage IIIB and IIIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

who mainly gets chemo after surgery (Stage)

A

I II IIIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

stage IV surgery?

A

no, only for symptomatic relief

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
adjuvant means what
after surgery
26
neoadjuvant means what
before surgery
27
radiation comes before or after surgery
after
28
what stages are we trying to cure
I, II, III
29
which HER2 patients should get chemo
tumor >0.6 cm HER2 targeted, chemo, hormone
30
HER2+ with tumor <0.5 reccomendation therapy
HER2 targeted +/- chemo endocrine therapy
31
SERM drug
tamoxifen
32
oophrectomy reccomended for who
premenopausal women with intact ovaries
33
LNRH analogs reccommended instead of what
taking out ovaries
34
LNRH analog drugs
leuprolide goserelin
35
side effect of leuprolide and goserelin
FSH and LH surge, hot flashes first 2-4 weeks
36
aromatase inhibitors for pre or post meno
post
37
aromatase inhibitors side effects
hot flashes osteoporosis muscle aches and pains
38
aromatase inhibitor drugs
anastrazole letrozole exemestane
39
premenopausal with intact ovaries hormonal treatment
tamoxifen for 5 years THEN 5 more years of tamoxifen or AI if no ovaries
40
premenopausal but ovary supression / ovary out
tamoxifen or AI x 5 years then either for 5 more years
41
if postmenopausal at diagnosis whats the ideal treatment
AI for 5 years + 5 more years
42
standard chemo length
4-6 cycles given every 3-4 weeks
43
most common chemo classes given in breast cancer
anthracyclines taxanes
44
HER2 negative chemo regimens
AC w paclitaxel TC
45
what is AC with paclitaxel consist of
doxorubicin cyclophosphamide paclitaxel every 2 weeks with CSFs
46
what is TC consist of and why would we use this
docetaxel cyclophosphamide if extensive cardiac history
47
what is dose dense
same dose shorter interval
48
HER2 negative patient with cardiac tox should do what
docetaxel + cyclophosphamide
49
HER2+ patients older treatment
APT paclitaxel trastuzumab (1 year)
50
HER2+ patients who are younger
TCH + P docetaxel carboplatin trastuzumab pertuzumab
51
how long should pts be on trastuzumab
1 yearr
52
triple negative chemo
paclitaxel carboplatin pemborlizumab THEN doxorubiucin cyclophosphamide pembrolizumab
53
how long should pembrolizumab be going for
1 year
54
er+ metastatic pts with long disease free survival, chemo or hormone?
hormone therapy
55
metastatic pts with short disease free survival agent
chemotherapy
56
metastatic HER2+ chemo regimen
trastuzumab pertuzumab docetaxel / paclitaxel
57
how long to continue trastuzumab and pertuzumab in metastatic disease
not a year
58
metastatic second line HER2 low
fam-trastuzumab
59
fam-trastuzumab used in who
1+ HER2 in metastatic
60
fam-trastuzumab side effect
shortness of breath
61
metastatic triple negative treatment
platinum pemborlizumab if 10+ score
62
what do we check if putting someone on CDK4/6 inhibitors
CBC monthly
63
which CDK4/6 has QTC prolongations
ribociclib
64
which CDK4/6 has diarrhea
abemaciclib
65
first and second line treatment in ER+ HER2- metastatic
1. AI + CDK4/6 2. everolimus + fulvestrant
66
what age should women start thinking about mammograms
40 years
67
what age should mammograms be yearly
45-54
68
which drugs can be used as preventative in high risk pts
tamoxifen raloxifene
69

PHRM 864 (28 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions