Other PRRs

Question 1

What do NLR respond to?

Answer 1

Cytosolic PAMP’s and DAMP’s

Form the inflammasome

Activate caspases-1 which then cleaves IL-1Betat and IL-18

Drive inflammation

Question 2

What does the Scavenger Receptor Family?

Answer 2

Class type I

Class type II

MARCO

Trimeric complexes of type II transmembrane proteins

Question 3

What are the 3 distinct extracellular structural domains?

Answer 3

SR cysteine-rich

Collagen-like domain which is implicated in the POLYANIONIC ligands

Alpha-helical coiled-coil doman

Question 4

What are the SR’s functions

Answer 4

Mediate the uptake of oxidized lipoproteins

Question 5

What does CD36 do?

Answer 5

It is a coreceptor in TLR2/6 recognition to lipoteichoic acid and diacylated lipopeptides.

SR bind via negative charge

Question 6

What are the receptors of Carbohydrates called?

Answer 6

C-type Lectin family

Have conserved domains

Mannose

L-fucose

N-acetyl-D-glucosamin

B-glucans

Question 7

What does NOD stand for and what do they do?

Answer 7

Nucleotide oligomerization domain

Specialized group of intracellular proteins

Regulate host innate immune response

Function as scaffolding proteins that assembler signaling platforms.

Control activation of inflammatory caspases