Molecules/Maturation Of Follicular B Lymphocytes Flashcards
1
Q
What chemokines are required for the B-cell homing process?
A
Requires CXCL12 and CCL19/21 on HEV
Chemokine receptors CXCR4/CCR7 and Naive B cells
2
Q
B-cells migrated into follicles in what Histo structure? And what drives them?
A
The stroma is the structure
Driven by CXCL13, the ligand
Recognized by CXCR5, the receptor
On naive B cells in Marginal Zone
3
Q
As B cells mature they express what receptor in response to what Chemokine?
A
They express Chemokine receptor CXCR5
Promotes movement into white pulp in response to CXCL13
