Molecules/Migration Of Navie/Effector T Cells

Question 1

Explain the combined role of CCL19 and 21 in migration of Naive an Effector T cell movement?

Answer 1

Activation of Integrins and chemokinesis

Ligand on endothelial cells

Question 2

What is the role of ICAM-1

Answer 2

Ligand on Endothelial cells

Stable arrest on HEV in LN\

Receptor is LFA-1 (Beta2- Integrin)

Question 3

What are the combine functions of E/P selections?

Answer 3

Ligands on Endothelial cell

Initial weak adhesion of effector and memory T cells to cytokin activation endothelium at peripheral site of infection

Receptors are E/P selectin ligand

Question 4

What is CXC10’s function?

Answer 4

Activation of Integrins and chemokinesis of activated and effector and memory T cells

Question 5

What is CCL4’s function?

Answer 5

Activation of Integrins and chemokinesis of activated and memory T cells

Question 6

What is the function of ICM-1 or VCAM-1

Answer 6

Stable arrest on cytokines- activated endothelium at peripheral site of infection

Receptors are LFA-1 (Beta2-Integrin) or VLA-4 (Beta1 Integrin)

Question 7

What is the function of CD44?

Answer 7

Binds to HA

Mobilization of effector T cells in inflammation and infection sites

Inside-out up regulation of VLA4-VCAM binding

Question 8

What is PNAd?

Answer 8

Peripheral lymph node addressin

Ligand on Endothelial cell

Initial weak adhesion on naive T cells to HEV in LN

T Cell receptor is L-seclectin