osteoporosis Flashcards
The most common disease of abnormal bone remodeling, involving an imbalance between bone formation and bone resorption, is …… pleaseeeeeee you know this
osteoporosis.
Osteoporosis is defined as a systemic impairment of bone (3), which increases the propensity of fragility fractures.
mass, strength, and microarchitecture
Diagnosis is based on a history of fragility fracture and/or bone densitometry (DXA) scan. _____ is a score which may be used to risk stratify patients with low bone density (T score between -1 and -2.5) and determine whether 10 year risk for fracture is high enough to warrant _____________.
Diagnosis is based on a history of fragility fracture and/or bone densitometry (DXA) scan. FRAX is a score which may be used to risk stratify patients with low bone density (T score between -1 and -2.5) and determine whether 10 year risk for fracture is high enough to warrant pharmacologic treatment.
Most current treatments for osteoporosis, including bisphosphonates, inhibit ________________, targeting the most common pathology behind osteoporosis. Three treatments ar_________ for bone including recombinant parathyroid hormone.
Most current treatments for osteoporosis, including bisphosphonates, inhibit resorption, targeting the most common pathology behind osteoporosis. Three treatments are anabolic for bone including recombinant parathyroid hormone.
Prior to treatment, patients must have a prerequisite (3)
dietary calcium intake, vitamin D and a program of weight-bearing exercise.
fractures in the setting of minimal trauma or following a fall from standing height or less
Fragility fractures –
WHO Definition based onon dual energy x-ray absorptiometry (DXA) score for osteoporosis
monoclonal Ab to RANK-L
Denosumab
clonal Ab to sclerostin
Romosozumab
1-34 PTH analog
teriparatide
first line treatment for osteoporosis
bisphosphonates
who to screen for osteroporosis?
all women above the age of 65 years
