diabetes medication

Question 1

matching diet and activity with insulin

Answer 1

type 1DM

Question 2

aim for 5-10% weight loss

Answer 2

type 2DM

Question 3

MOA metformin

Answer 3

Inhibition of gluconeogenesis at the liver

Question 4

insulin secretion?

Answer 4

24 hr basal secretion but bolus after meals

Question 5

Suppresses glucose production between meals and overnight

40% to 50% of daily needs

Answer 5

Basal insulin

Question 6

Limits hyperglycemia after meals
Immediate rise and sharp peak at 1 hour
10% to 20% of total daily insulin requirement at each meal

Answer 6

bolus insulin (mealtime)

Question 7

glucagon rescue

Answer 7

For emergency use if unable to resolve hypoglycemia with oral glucose

Question 8

Glyburide, glipizide (immediate and extended release), glimepiride

Answer 8

sulfonylureas

Question 9

sulfonylureas and glinides MOA

Answer 9

All work through closing beta cell potassium channel

Question 10

glitazone MOA

Answer 10

activate a novel nuclear receptor (PPAR-gamma) in adipose tissue and improve insulin sensitivity in other tissues

Question 11

black box for heart failure risk

Answer 11

glitazone

Question 12

GI hormones that cause an increase in the amount of insulin released when glucose levels are normal or particularly when they are elevated.

Answer 12

incretins

Question 13

reduce CV events in high risk patients

Answer 13

GLP-1 agonist

Question 14

breaks down endogenous GLP-1

Answer 14

DPP

Question 15

gliptins MOA

Answer 15

inhibits the breakdown of GLP-1

Question 16

Flozin MOA

Answer 16

Block renal glucose reabsorption by blocking the SGLT2 transporter in the kidney

Question 17

alpha- glucosidase inhibitor MOA

Answer 17

Work by inhibition of enzymes in the intestinal brush border

Question 18

Lifestyle management with diet and activity is the pedestal of all diabetes management. Weight loss, when overweight, is important including a role for bariatric surgery

Answer 18

yep

Question 19

Insulin may be used in any subtype of diabetes but is essential for type ___ diabetes. Think basal and bolus!

Answer 19

1

Question 20

Insulin secretagogues work at the ________ to increase insulin secretion.

Answer 20

pancreas

Question 21

Bariatric surgeries including primarily sleeve gastrectomy and gastric bypass may all improve glycemic control and weight for patient with BMI over 35 and diabetes.

Answer 21

YEP