Oral Pathology Flashcards
what causes okc
Genetically, OKC shows a repeatable chromosomal abnormality (PTCH gene on chromosome 9q22.3-q31). It is derived from the rests of the dental lamina (rests of Serres). Histologically, the cyst is linted by a thin layer of parakeratotic stratified squamous epithelium, which is usually 6-8 cell layers thick. Lacks rete ridges. The basal cell layer is hyperchromatic and composed of cuboidal cells, which shows a prominent palisading, giving a “tombstone” effect
any syndromes associated with OKC
criteria for Nevoid Basal Cell Carcinoma Syndrome: Dx with 2 major or 1 major and 2 minor:
Major:
-Mutliple (>2) basal cell carcinomas, or one in a patient under 30, or >10 basal cell nevi
-Any OKC or polyostoic bone cyst
-Palmar or plantar pits (3 or more)
-Ectopic calcification: lamellar or early (< age 20) falx calcification
-Family hx of NBCCS
how does a dentigerous cyst form
tigerous cysts are developmental in origin. It forms as a consequence of the buildup of fluid between the dental follicle (reduced enamel epithelium) and the crown of an unerupted tooth
What is characteristics central giant cell tumor
histologically similar to browns tumor (hyperparathyroidism)(giant cells)
Diagnosis for aggressive and nonaggressive CGCT
Major
>5cm or recurrence after treatment.
Minor
Rapid growth, Displacement of the tooth, tooth or root resorption.
treatment of Central giant cell tumor
E&C has 20% recurrence
could en block with 1 cm margins
Conservative:
Intralesional steroids for 6 weeks
denosumab or bisphosphonates
What is leukemia
disease of mesenchymal cells with abnormal proliferation of myeloid or lymphoid cells.
what is the most likely diagnosis for childhood leukemia?
ALL accounts for 2/3 of childhood. high curative rates. Acute lymphocytic leukemia
what are myeloid precursors? types of cells
rbc, macrophages. platelets
lymphoid precursor?
T cells. NK cells, B cells
What systemic disorder is fibrous dysplasia linked to?
McCune-albright: precocious puberty, hyperparathyroidism, cafe au lait spots?
Jaffe-lichenstein: cafe au lait without the endocrinopathy
what is pre-eclampsia
abnormal implantation of the placenta which leads to HTN
what is eclampisia
severe eclampsia with seizures or coma
what is CEOT
Calcifying epithelial odontogenic tumor
Benign odontogenic tumor that is locally aggressive
what is the most characteristic histological feature of a COC
ghost cells within the epithelial component.
