ophthalmology Flashcards
Describe afferent defect in the pupils
- No direct response, therefore no consensual response in contralateral eye
- Consensual response intact
- Dilation on moving light from normal eye to abnormal eye
Cause of afferent defect in pupil
CN II lesion
What is a relative afferent pupillary defect
- marcus gunn pupil
- minor constriction to direct light
- dilation on moving light from normal eye to abnormal eye
causes of RAPD?
optic neuritis (maybe MS) optic atrophy retinal disease (detachment)
symptoms of efferent defect
- dilated pupil does not react to light
- initiates consensual response in contralateral pupil
- ophthalmoplegia (paralysis of the muscles) and ptosis
causes of efferent defect
3rd nerve palsy
symptoms of a 3rd nerve palsy
ptosis down and out dilated pupil (often spared in a vascular lesion e.g. DM) as pupillary fibres run in the periphery
causes of 3rd nerve palsy
vascular
DM
compression (tumour, coning)
differential of a fixed dilated pupil
mydriatics e.g. atropine
iris trauma
acute glaucoma
CN3 compression (tumour, coning)
symptoms of Holmes Adie pupil
- young woman with sudden blurring of near vision
- dilated pupil has no or sluggish constriction response to light (accommodation)
- starts unilaterally then is bilateral
- then constricted pupils stays constricted for a long time
investigation of holmes adie tonic pupil
slit lamp
iris shows spontaneous wormy movements and iris streaming
cause of holmes adie tonic pupil
- damage to post ganglionic parasympathetic fibres
- viral
what is holmes adie syndrome
holmes adie pupil (tonic) + absent knee/ankle jerks + decreased BP
symptoms of Horners syndrome
PEAS ptosis enophthalmos anhydrosis small pupil (miosis)
causes of horners syndrome
- central - MS, Wallenbergs lateral medullary syndrome
- pre ganglionic (neck) - pancoasts tumour (T1 nerve root lesion), trauma (from CVA insertion of CEA)
- post ganglionic - cavernous sinus thrombosis (usually 2ary to spreading facial infection via the ophthalmic veins, CN 3,4,5,6, palsies), carotid artery dissection
investigations in horners
CT/MRI head for stroke
symptoms of argyll robertson pupil
- small, irregular pupils
- accommodate but don’t react to light
- atrophied and depigmented iris
cause of argyll robertson pupil
DM
quaternary syphillis
function of the parasympathetic and sympathetic nervous system in the pupils
SNS - causes dilation (therefore issue is horners causes miosis)
PNS - causes constriction (therefore issue is adies tonic pupil causing dilation)
what is miosis and mydriasis
miosis = small mydriasis = big
causes of bilateral miosis pupils
opiates and central pontine haemorrhage
causes of bilateral mydriasis pupils
sympathetics (cocaine), antihcolinergics, topical mydriatics (atropine and tropicamide)
symptoms of optic neuritis / neuropathy
- reduced acuity
- reduced colour vision (esp red) [dyschromotopia]
- central scotoma (sudden LOV over hours to days)
- pale optic disc
- RAPD
- pain on eye movement
causes of optic neuropathy
CCAC VISION
C - common - MS, glaucoma
C - congenital - Leber’s, Friedrichs ataxia, DIDMOAD, retinitis pigmentosa
A - alcohol [and other toxins], lead, ethambutol, B12 def
C - compression - neoplasia, glaucoma, pagets
V - vascular - DM, GCA, thromboembolic
I - inflammatory - MS
S - sarcoid
I - infectious - herpes zoster, TB, syphilis
O - papilloedema
N - neoplastic - lymphoma, leukaemia