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Neuroscience 111 > Oof And Itch > Flashcards

Oof And Itch Flashcards

1
Q

What does the somatic system depend on?

A

Nociceptors

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2
Q

Describe a nociceptor

A

Free, branching unmyelinated nerve endings that signal pain

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3
Q

Do nociceptors have the same path to the brain as mechanoreceptors?

A

Nope

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4
Q

What is nociception?

A

SEnsory process that provides signals that trigger pain

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5
Q

Can there be pain without nociception?

A

Yes, some throbbing sensations

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6
Q

What activates nociceptors?

A

Substances from damaged cells
- proteases
- ATP
- K+ channels
- histamines

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7
Q

What type of fibers are responsible for transduction of pain?

A

Unmyelinated C/Type 4
&
Thinly myelinated Adelta/Type 3

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8
Q

Nociceptors are ___modal

A

Poly

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9
Q

What is polymodal?

A

It can respond to several types of stimuli

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10
Q

What are the 3 types of things that can activate nociceptors?

A

Mechanical pressure, thermal pressure, and chemical pressure (like histamines)

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11
Q

What type of receptors control itch?

A

Pruriceptors

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12
Q

What type of fibers are used for the itch sensation?

A

C fibers

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13
Q

What channels are activated when histamine is present?

A

TRPV1 channels

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14
Q

Is all itch histamine mediated?

A

Nope

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15
Q

What type of fiber is used for the FIRSt pain? Describe it

A

Type 3/Adelta, fast and sharp

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16
Q

What type of fibers are used for SECOND pain? Describe it

A

C fiber activation, duller and longer lasting

17
Q

Where do the second and first pain synapse to?

A

Substantial gelatinosa (basically the top left and right of the spinal butterfly)

18
Q

What do 2nd order neurons do from the spine?

A

Decussate and ascend

19
Q

What is the main neurotransmitter of pain afferents?

A

Glutamate

20
Q

Which pathway do pain and temperature take to get to S1?

A

Spinothalamic

21
Q

Where do the axons decussate in the spinothalamic pathway? And ascend via what?

A

Spinal cord, the spinALthalamic pathway

22
Q

Do fibers in the spinothalamic pathway synapse anywhere before getting to S1?

A

No

23
Q

What is the Gate Theory of Pain?

A

Why rubbing an injury is done

24
Q

What is the projection neuron inhibited by?

A

An interneuron

25
Q

What is an interneuron excited by?

A

Large sensory axons

26
Q

What happens when mechanoreceptors axon signals simultaneously with nociceptors?

A

Nociception suppressed

27
Q

What is referred pain?

A

Pain felt somewhere different from injury site (ex. Heart attack you can feel pain in your sides or jaw)

28
Q

What causes referred pain?

A

Two areas axons being close together in dorsal horn

29
Q

I have a headache

A

Same

Neuroscience 111 (14 decks)

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