OneNote Notes AoS 1 Flashcards

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1
Q

What are the two key pathways of apoptosis?

A

Mitochondrial pathway
Death receptor pathway

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2
Q

The Death receptor pathway is also known as…

A

The extrinsic pathway

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3
Q

The mitochondrial pathway is caused due to….

A

cell stress

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4
Q

The death receptor pathway is caused due to….

A

immune cells

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5
Q

Both the mitochondrial pathway and death receptor pathway activates?

A

Caspase enzyme

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6
Q

The caspase enzyme causes?

A

Cell death

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7
Q

Steps of the mitochondrial pathway

A
  1. Cell is damaged by malfunctioning
  2. Mitochondria defeat this
  3. Mitochondria release cytochrome c into the cytosol
  4. Cytochrome c binds to cytosolic proteins to form an apoptosome
  5. Apoptosome activates caspase enzyme initiating apoptosis
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8
Q

Steps of the death receptor pathway

A
  1. Death signaling molecules released by other cells
  2. These molecules are recognized by death receptors
  3. When the molecules bind to the receptors, caspase enzyme is triggered.
  4. Caspase enzyme triggers apoptosis
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9
Q

Steps of apoptosis.

A
  1. Caspase enzyme activated
  2. Digestion of cell contents
  3. Cell shrinks
  4. Membrane blebbing
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10
Q

What is phagocytosis?

A

Endocytosis of apoptotic bodies by phagocytes

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