oncology midterms Flashcards
enumerate the lesions under malignant non-odontogenic tumors
osteosarcoma, juxtacortical osteosarcoma (periosteal and parosteal), chondrosarcoma, burkitts lymphoma, ewings sarcoma, multiple myeloma, solitary plasmacytosis, metastatic carcinoma
the second most common malignancy of the bone
osteosarcoma
paresthesia is due to the
impingement of the inferior alveolar enrve1
maxillary osteosarcoma oresents the same pattern but may also cause:
impingement of ian, epistaxis, nasal obstruction, eye problems (proptosis and diplopia)
the most common subtype of osteosarcoma is
chondroblastic osteosarcoma
3 types of osteosarcoma based on the site of origin
conventional, juxtacortical, extraskeleteal
localized widening of the PDL space of one or two teeth
early osteosarcoma involving alveolar process
treatment of osteosarcoma includes
surgical management, chemotherapy, radical mandibullectomy, and maxillectomy
true or false osteosarcomas are more likely to metastaasize to the lungs, regional lymph nods and brain
true
t or f: parosteal is more common than periosteal
true
not covered by lining epithelium
parosteal osteosarcoma
common location of periosteal osteosarcoma
upper tibial metaphysis
common locatioon of parosteal osteosarcom
distal femoral metaphysic
long standing slow growing selling or palpable mass often accomanied by dull aching sensation
parosteal osteosarcoma
parosteal osteosarcoma can be mistakenly diagnosed as
gout
true or false: parosteal osteosarcoma has a more ossified base than periphery
false: more ossified periphery than base
radiographically is radiodense and is attached tot he external surface of bone
parosteal osteosarcoma
treatment for parosteal osteosarcoma
en bloc resection
covered by lining epithelium
periosteal osteosarcoma
t or f females are more susceptible to periosteal osteosarcoma
false: males 2:1 ratio
radiographic appearance of periosteal osteosarcoma
radiolucent
a radiographic shadow between the raised ends of periosteum and cortical bone due to reactive bone formation
codmans triangle
it is the third most common malignancy of the bone
chondrosarcoma
location of chondrosarcoma in the maxilla
lateral incisor and canine region, and palate
location of chondrosarcoma in the mandible
premolar-molar region
symphysis
coronoid and condylar process
loosening of teeth and ill fitting dentures are clinical features of this lesion
chondrosarcoma
describe the histopathological grading of chondrosarcoma
grade 1; well differentiate, lobular
grade 2: intermediate, myxoid stroma
grade 3: poorly differentiated, spindle cell components
moth eaten radiolucency or diffusely opaque lesions unilocular or multilocular
chondrosarcomas
where does chondrosarcoma metastasize?
lungs and bone
other name of ewings sarcoma
primitive neuroectodermal tumor
etiology of ewings sarcoma
translocation of chromosomes 11 and 22
clinical features of ewings sarcoma
pain and swwlling and mucosal expansion
facial deformitu and destruction of alvelar bone with loosening of teeth
salient histopathologic feature of ewings sarcoma is the presence of ________ which is stained by _________
glycogen; schiffs stain
may simulate infectious processes as well as malignant processes
ewing sarcoma
treatments for ewings
multiple method protocols
surgery
chemotherapy
translocation of the distal part of chromosomes 8-14
burkitts lymphoma
two forms if burkitts lymphma
endemic and sporadic
t or f: burkittls lymphoma is not curable
false: it is potentially curable
what are the 2 plasma cell neoplasm
multiple myeloma and solitary plasmacytoma of the bone
occurs spontaneously or when pt. are exposed to pesticide dioxin or ionizing radiation
multiple myeloma
most common location of pathologic fractures include
the spine, ribs and pelvis
a fracture caused by tumors
pathologic fractures
bence jones protein
multiple myeloma
standard treatment for multiple myeloma
melphalan and prednisone
patients in whome therapy is ineffective alternative drugs include
VBMCP= vincristine, carmustine, melpahalan, clorophosphamide, prednisone
VAD= vincristine, adriamycine, dexamethasone
VBMCP AND VAD can cause
muscle weakness and increase chance of infectiosn
