analgesics Flashcards

1
Q

a drug which relieves pain without loss of consciousness

A

analgesics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

drugs with antipyretic, antiinflammatory, and analgesic effects

A

NSAIDS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

NSAIDs stand for

A

non steroidal anti inflammatory drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

2 main groups of analgesics

A

a. opioid/morphine like
b. non opioid/ aspirin like

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

it is the most important opium

A

morphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the 3 opioid receptor in the system

A

mu, delta, kappa receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

explain pain perception

A

a. nociceptors- will detect stimulus
b. secondary neurons- carry message
c. spinal cord (dorsal horn)- receive message and bring it to the brain
d. hypothalamus- perceives sitmulus as pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

3 neurotransmitters in the pre synaptic neuron for pain

A

substance p, glutamate, cgrp (calcitonin gene related peptide)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MOA of opioids

A

a. opioids act on receptors (mu delta kappa)
b. opening of potassium channels- K will leave to reduce sensitivity to excitatory pain signals and inhibitors
c. closing of calcium- less activation of the 3 neurotransmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

synthetic opioids

A

hydrocodone, hydromorphone, oxycodone, oxymorphone,fentanyl,mepiradine,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

potent antagonist and agonist of both NMDA and AMPA

A

Methadone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

mixed agonist and antagonist

A

buprenorphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

naloxone

A

is an antagonist of opioids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

cox 1

A

thromboxane prostaglandin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

identify if cox 1 or cox 2
a. fever

A

cox 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

identify if cox 1 or cox 2:
induced by the body

17
Q

identify if cox 1 or cox 2:
renal perfusion

18
Q

identify if cox 1 or cox 2:
platelet aggregation.activation

19
Q

identify if cox 1 or cox 2:
platelet inhibition

20
Q

MOA of NSAIDS

A

block cox1 and cox2 enzymes

21
Q

what nsaids are given to mild to moderate pain

A

low dose of ibuprofen and paracetamol

22
Q

paracetamol is an NSAID t or F

A

F- not an nsaid, does not have anti inflammatory effects

23
Q

post extraction drugs

A

ketorolac, propionic acid derivatives, diclofenac

24
Q

acetaminophen and etoricoxib can not be given to patients with gastric problems, T or F

A

F- can be given

25
patients with anaphylactoid reaction to aspirin
any cox 2 inhibitors (meloxicam, diclofenac, celecoxib)
26
pediatric patients
paracetamol, aspirin, ibuprofen, naproxen
27
swelling of brain and liver, associated with aspirin during viral infection
reyes sydrome
28
pregnant women
paracetamol is the safest: low dose of aspirin
29
CVD and stroke
avoid etoricoxib and celecoxibs could be given ibuprofen and low dose of aspirin