cell necrosis Flashcards
two types of cell death
apoptosis and necrosis
gross histologuc correlate of cell death
necrosis
what organelle causes cell death due to its enzymes
lysosomes
apoptosis always has inflammation
false
morphology od necrosis under microscope
increased eosinophilia, myelin figures, glassy homogenous figures, nucleu¥ar changes, calcification
develops presence of denaturation
coagulative necrosis
does not denote pattern of necrosis
fat necrosis
seen in the brain
liquefactive necrosis
cheesy white gross appearance
caseous necrosis
fat necrosis is due to
fat lipases
due to focal bacterial or fungal
liquefactive necrosis
induced by tightly regulated intracellular program
apoptosis
radiationa nd cytotoxic drugs are
phatological apoptosis
cell breadown during menstruation is
physiological
when lymphocytes and monocytes die is
physiological
other name of monocytes
polymorphonuclears
manifestations of metabolic derrangement in cells
intracellular accumulations
where does intracellular accumulation happen
nucleus or cytoplasm
due to genetic or acquired defects in metabolism, packaging, transport or secretion
normal and abnormal endogenous substance
abnormal exogenous substances
deposited inside the cell and increase in number
gives color
pigments
example of lipids
triglycerides, cholesterol, cholesterol esthers, phospholipids
abnormal accumualtions of triglycerides
steatosis or fatty change
used by cell in the synthesis of cell membrane
cholesterol and cholesterol estherse
round eosinopjilic droplets vacuoles or aggregates in the cytoplasm
proteins
hyaline change
changes within cells or extracellular space
where is glycogen stored
liver
most common exogenous pigments
coal, carbon
also known as the wear and tear pigment
lipofuscin
melanin is derived from hemoglobin T or F
false
main cause of lipofuscin accumualtion
cachexia or malnutrition
ochronosis is seen in the accumulation of
hemogentisic acid
black urine
alkaptonuria
hemoglobin derived golden yellow to bron pigment
hemosiderin
ferritin gives rise to
hemosiderin
dpa or dihydroxyphenylalanin produced
tyrosine plus tyrosine catalase
accumulation of iron in the liver
hemochromatosis
normal major pigment in bile
billirubin
PTH;CALCITONIN
BONE TO BLOOD: BLOOD TO BONE
