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NAPLEX > Oncology II > Flashcards

Oncology II Flashcards

1
Q

SERMs are used for?

A

pre- and post menopausal

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2
Q

Aromatade inhibitors are used for?

A

postmenopausal

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3
Q

Examples of SERMs

A

tamoxifen, fulvestrant, raloxifene, toremifene

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4
Q

Soltamox

A

tamoxefen

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5
Q

Faslodex

A

fulvestrant

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6
Q

Evista

A

raloxifene

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7
Q

Fareston

A

toremifene

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8
Q

Examples of aromatase inhibitors

A

anastrozole, letrozole, exemestane

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9
Q

Arimidex

A

anastrozole

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10
Q

Femara

A

letrozole

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11
Q

Aromasin

A

exemestane

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12
Q

Ibrance

A

palbociclib

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13
Q

MOA of lupronand zoladex

A

GnRH agonists

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14
Q

Lupron, Depot, Eligard

A

leuprolide

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15
Q

Zoladex

A

goserelin

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16
Q

MOA of firmagon

A

GnRH antagonist

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17
Q

Firmagon

A

degarelix

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18
Q

MOA of casodex, nilandron?

A

first generation antiandrogens in combo with GnRH agonists

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19
Q

Casodex

A

bicalutamide

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20
Q

Nilandron

A

nilutamide

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21
Q

MOA of Xtandi

A

2nd generation antiandrogen

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22
Q

Xtandi

A

enzalutamide

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23
Q

MOA of zytiga

A

Androgen biosynthesis inhibitor to decrease testosterone production

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24
Q

Zytiga

A

abiraterone

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25
Q

Abiraterone is given with?

A

prednisone

26
Q

M phase?

A

mitosis - cell divides into 2 cells

27
Q

G0 phase?

A

resting phase pose mitosis

28
Q

G1 phase?

A

Post-mitotic phase- where enzymes and proteins are synthesized

29
Q

S phase?

A

DNA synthesis and duplication occurs

30
Q

G2 phase?

A

pre-mitotic phase-RNA and proteins are produced to prepare for cell division

31
Q

What are non-cell cycle specifics?

A

alkylating agents, anthracyclines, platinum agents

32
Q

Alkylating agents?

A

cyclophosphamide, carmustine, procarbazine, busulfan, melphalan

33
Q

Cytoxan

A

cyclophosphamide

34
Q

Ifex

A

ifosfamide

35
Q

Binu, Gliadel, Wafer

A

carmustine

36
Q

Bendeka, Treanda

A

bendamustine

37
Q

Myleran, Busulfex

A

busulfan

38
Q

Alkeran, Evomela

A

melphalan

39
Q

Examples of platinum based compounds?

A

Cisplatin, carboplatin, oxaliplatin

40
Q

Platinol

A

cisplatin

41
Q

Paraplatin-AQ

A

carboplatin

42
Q

Eloxatin

A

oxaliplatin

43
Q

Examples of Anthracyclines?

A

Doxorubicin, mitoxantrone

44
Q

Adriamycin

A

doxorubicin

45
Q

What to do for vinca alkaloids if turned into vesicant

A

warm compress and hyaluronidase

46
Q

Vincristine and _______ can increase severe toxicities?

A

azole antifungals

47
Q

Vincasar PFS

A

vincristine

48
Q

Vinorelbine

A

vinblastine

49
Q

Marqibo

A

vincristine liposomal

50
Q

Examples of Taxanes?

A

paclitaxel, docetaxel, paclitaxel

51
Q

MOA of taxanes?

A

inhibit the function of microtubules during M phase

52
Q

Taxol

A

paclitaxel

53
Q

Taxotere

A

docetaxel

54
Q

Jevtana

A

cabazitaxel

55
Q

Abraxane

A

paclitaxel albumin-bound

56
Q

Camptosar

A

irinotecan

57
Q

VePsod

A

etoposide capsules

58
Q

Xeloda

A

capecitabine

59
Q

Alimta

A

pemetrexed

60
Q

Trecall, Otrexup, Rasuvo, Xatmep

A

methotrexate

61
Q

Velcade

A

bortezomib

62
Q

Kyprolis

A

carfilzomib

NAPLEX (13 decks)

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