Oncology II

Question 1

SERMs are used for?

Answer 1

pre- and post menopausal

Question 2

Aromatade inhibitors are used for?

Answer 2

postmenopausal

Question 3

Examples of SERMs

Answer 3

tamoxifen, fulvestrant, raloxifene, toremifene

Question 4

Soltamox

Answer 4

tamoxefen

Question 5

Faslodex

Answer 5

fulvestrant

Question 6

Evista

Answer 6

raloxifene

Question 7

Fareston

Answer 7

toremifene

Question 8

Examples of aromatase inhibitors

Answer 8

anastrozole, letrozole, exemestane

Question 9

Arimidex

Answer 9

anastrozole

Question 10

Femara

Answer 10

letrozole

Question 11

Aromasin

Answer 11

exemestane

Question 12

Ibrance

Answer 12

palbociclib

Question 13

MOA of lupronand zoladex

Answer 13

GnRH agonists

Question 14

Lupron, Depot, Eligard

Answer 14

leuprolide

Question 15

Zoladex

Answer 15

goserelin

Question 16

MOA of firmagon

Answer 16

GnRH antagonist

Question 17

Firmagon

Answer 17

degarelix

Question 18

MOA of casodex, nilandron?

Answer 18

first generation antiandrogens in combo with GnRH agonists

Question 19

Casodex

Answer 19

bicalutamide

Question 20

Nilandron

Answer 20

nilutamide

Question 21

MOA of Xtandi

Answer 21

2nd generation antiandrogen

Question 22

Xtandi

Answer 22

enzalutamide

Question 23

MOA of zytiga

Answer 23

Androgen biosynthesis inhibitor to decrease testosterone production

Question 24

Zytiga

Answer 24

abiraterone

Question 25

Abiraterone is given with?

Answer 25

prednisone

Question 26

M phase?

Answer 26

mitosis - cell divides into 2 cells

Question 27

G0 phase?

Answer 27

resting phase pose mitosis

Question 28

G1 phase?

Answer 28

Post-mitotic phase- where enzymes and proteins are synthesized

Question 29

S phase?

Answer 29

DNA synthesis and duplication occurs

Question 30

G2 phase?

Answer 30

pre-mitotic phase-RNA and proteins are produced to prepare for cell division

Question 31

What are non-cell cycle specifics?

Answer 31

alkylating agents, anthracyclines, platinum agents

Question 32

Alkylating agents?

Answer 32

cyclophosphamide, carmustine, procarbazine, busulfan, melphalan

Question 33

Cytoxan

Answer 33

cyclophosphamide

Question 34

Ifex

Answer 34

ifosfamide

Question 35

Binu, Gliadel, Wafer

Answer 35

carmustine

Question 36

Bendeka, Treanda

Answer 36

bendamustine

Question 37

Myleran, Busulfex

Answer 37

busulfan

Question 38

Alkeran, Evomela

Answer 38

melphalan

Question 39

Examples of platinum based compounds?

Answer 39

Cisplatin, carboplatin, oxaliplatin

Question 40

Platinol

Answer 40

cisplatin

Question 41

Paraplatin-AQ

Answer 41

carboplatin

Question 42

Eloxatin

Answer 42

oxaliplatin

Question 43

Examples of Anthracyclines?

Answer 43

Doxorubicin, mitoxantrone

Question 44

Adriamycin

Answer 44

doxorubicin

Question 45

What to do for vinca alkaloids if turned into vesicant

Answer 45

warm compress and hyaluronidase

Question 46

Vincristine and _______ can increase severe toxicities?

Answer 46

azole antifungals

Question 47

Vincasar PFS

Answer 47

vincristine

Question 48

Vinorelbine

Answer 48

vinblastine

Question 49

Marqibo

Answer 49

vincristine liposomal

Question 50

Examples of Taxanes?

Answer 50

paclitaxel, docetaxel, paclitaxel

Question 51

MOA of taxanes?

Answer 51

inhibit the function of microtubules during M phase

Question 52

Taxol

Answer 52

paclitaxel

Question 53

Taxotere

Answer 53

docetaxel

Question 54

Jevtana

Answer 54

cabazitaxel

Question 55

Abraxane

Answer 55

paclitaxel albumin-bound

Question 56

Camptosar

Answer 56

irinotecan

Question 57

VePsod

Answer 57

etoposide capsules

Question 58

Xeloda

Answer 58

capecitabine

Question 59

Alimta

Answer 59

pemetrexed

Question 60

Trecall, Otrexup, Rasuvo, Xatmep

Answer 60

methotrexate

Question 61

Velcade

Answer 61

bortezomib

Question 62

Kyprolis

Answer 62

carfilzomib