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Chronic Heart Failure Flashcards

1
Q

What EF is considered HFrEF?

A

40%

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2
Q

Normal EF?

A

55-70%

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3
Q

what is considered impaired ventricular relaxation and filling during diastole?

A

> 50%

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4
Q

what is cardiac output?

A

volume of blood that is pumped by the heart in one minute

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5
Q

Drugs that worsen chronic HF

A

antiarrhythmics, oncology, non-DHP CCB, TDZs, NSAIDS, immunosippressants, itraconazole, systemic steroids, amphetamines, triptans, excessive alcohol

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6
Q

Loop diuretic MOA?

A

block reabsorption in the ascending limb of loop of henle

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7
Q

Loops increase excretion of?

A

sodium, potassium, chloride, magnesium, calcium, and water

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8
Q

Lasix

A

furosemide

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9
Q

Bumex

A

Bumetanide

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10
Q

Demadex

A

torsemide

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11
Q

Edecrin

A

ethacrynic acid

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12
Q

Oral equivalent dosing for loop diuretics?

A

furosemide 40 mg = bumetanide 1 mg = torsemide 20 mg = ethacrynic acid 50 mg

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13
Q

Capoten

A

captopril

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14
Q

Vasotec

A

enalapril

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15
Q

Prinivil, Zestril, Qbrelis

A

lisinopril

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16
Q

Aceon

A

perindopril

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17
Q

Accupril

A

quinapril

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18
Q

Altace

A

ramipril

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19
Q

Mavik

A

trandolapril

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20
Q

Atacand

A

candesartan

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21
Q

Cozaar

A

losartan

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22
Q

Diovan

A

valsartan

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23
Q

Function of neprilysin?

A

degradation of several beneficial vasodilatory peptide

24
Q

Entresto

A

sacubitril/valsartan

25
Q

Beta 1 selective

A

bisoprolol and metoprolol succinate

26
Q

non-selective BB and alpha 1 blocker

A

carvedilol IR and ER

27
Q

when to not use BB

A

stop in acute decomposition only in ADHF if hypotension and hypoperfusion

28
Q

Zebeta

A

bisoprolol

29
Q

Toprol XL

A

metoprolol succinate

30
Q

Coreg

A

carvedilol

31
Q

when to decrease dose of BB if HR is?

32
Q

Metoprolol IV to PO

33
Q

Which hypoglycemia symptoms are not masked with BB?

A

sweating and hunger

34
Q

How do non selective BB casue hyperglycemia?

A

decrease insulin secretion

35
Q

MOA of aldactone?

A

compete with aldosterone at the receptor sites in distal convoluted tubule and collecting ducts

36
Q

Aldactone

A

spironolactone

37
Q

CaroSpir

A

spironolactone suspension

38
Q

Inspra

A

eplerenone

39
Q

when to not start ARA?

A

K> 5 mEq/L, SCr 2.5 (male) and >2 (female), CrCl < 30

40
Q

MOA of hydralazine?

A

arterial vasodilator which decrease afterload

41
Q

MOA of nitrate?

A

increase availability of nitric oxide which cause venous vasodilation and decrease preload

42
Q

BiDil

A

hydralazine and isosorbide dinitrate

43
Q

What to not take nitrates with?

A

PDE-5 inhibitors and riociguat

44
Q

Monoket and Imdur

A

isosorbide mononitrate

45
Q

Isordil titradose, Dilatrate SR

A

isosorbide dinitrate

46
Q

MOA of Digoxin

A

inhibits NA/K ATPase pump

47
Q

Digiteck, Digox, Lanoxin

48
Q

therapeutic range of digoxin in HF?

49
Q

Antidote to digoxin

50
Q

S/Sx of digoxin toxicity?

A

N/V, loss of appetite and bradycardia

51
Q

MOA of ivabradine?

A

inhibitor of the funny current (If) to reduce sinus rate and HR

52
Q

Carlanor

A

ivabradine

53
Q

Ivabradine indicated in pts?

A
  1. stable symptomatic chronic HF
  2. LVEF < 35
  3. BB > 70
  4. on max tolerated doses of BB
54
Q

target HR for ivabradine?

55
Q

Klor-Con, Klor-Con M20, MicroK

A

potassium chloride

56
Q

usual range of K

NAPLEX (13 decks)

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