Ch. 49 Hypertension Flashcards
Drugs that can cause high BP
amphetamines, cocaine, decongestants, ESAs, immunosuppressants, NSAIDs, systemic steroids, alcohol, appetite suppressants, caffeine, SNRIs, oral contraceptives, oncology drugs mirabegron (beta-3 agonist)
BP goal for 18-59 y/o (no DM or CKD)
<140/90
BP goal for CKD and/or DM (all ages)
<140/90
BP < 150/90 mmg: age > 60 (no DM or CKD)
<150/90
drug selection for non-black pt?
thiazide, CCB, ACE, ARB
drug selection for black pt ?
thiazide, CCB
CKD+- albuminuria +- DM?
ACE or ARB
What to do if BP is > 160/100?
consider to start 2 drugs
When should a pregnant women be treated?
> 160/105
Agents to use in a pregnant women?
labetalol, nifedipine, methyldopa
MOA of thiazide diuretics
inhibit NA and water reabsorption in distal convoluted tubules – excrete Na, h20, K, H
thiazide diuretics can increase which electrolytes?
Ca, HCO3, LDL, TG, BG, Uric acid
Diuril
chlorothiazide
Microzide
hydrochlorothiazide
MOA of DHP CCB
work on peripheral vascular smooth muscle decrease SVT and BP —> reflex tachycardia, HA, flushing and peripheral edema
MOA of non-DHP CCB
work on cardiac smooth muscle , decrease HR and contractility, and BP
example of non-DHP CCB
verapamil and diltiazem
Norvasc
amplodipine
Adalat CC, Procardia XL
nifedipine ER
Sular
nisoldipine ER
Cardene IV
nicardipine IV
Cleviprex
clevidipine
Cardizem, Cartia, Diltazac, Tiazac
diltiazem
Calan, Covera HS, Verelan
verapamil