CH. 46 migraine Flashcards
What are the phases of migraine
vulnerability –> prodrome (24h) –> Aura (1h) –> Headache (3 hours to days) –> Post headache state
What are possible causes of migraine?
vasodilation of the cranial blood vessels, hyper-excitable neurons, genetic, women > men
Common migraine triggers?
Hormonal changes, food (alcohol, MSG, red wine, aged cheese) stress, sensory stimuli, changes in sleep-wake pattern, changes in environment
Natural products for migraine
Butterbur, Coenzyme Q10, feverfew, magnesium, peppermint (topically), riboflavin
MOA of triptans
selective 5-HT1 receptor agonists and cause vasoconstriction of cranial blood vessels
Amerge
naratriptan
Axert
Almotriptan
Frova
Frovatriptan
Imitrex, sumavel, Zembrace, Onzetra xsail
sumatriptan
Maxalt
rizatriptan
Relpax
eletriptan
Zomig
zolmitriptan
What is the oldest triptan?
sumatriptan
Treximet
sumatriptan and naproxen
Which triptan are ODT?
rizatriptan and zolmitriptan
Which triptan have a PED indication?
almotriptan, zolmitriptan nasal spray, treximet > 12 and rizatriptan > 6
Migranal and D.H.E
dihydroergotamine
Cafergot and Migergot
Ergotamine and caffeine
MOA of ergotamine
nonselective agonist of serotonin receptors causing vasoconstriction
Type of medication used for prophylactic treatment?
antihypertensives 9BB), Antiepileptic, antidepressants, oral contraceptive, botox
Indreal LA
propranolol
Lopressor, toprol XL
metoprolol
BB used for migraine
propranolol, timolol, metoprolol
Antiepileptic drugs used for migraine?
Topiramate, valproic acid
