Ch. 47 Gout

Question 1

Gout is caused by?

Answer 1

build up of uric acid crystals mainly in the joints

Question 2

Gout symptoms?

Answer 2

inflammation, pain, redness, stiffness, swelling

Question 3

Uric acid is a byproduct of?

Answer 3

Purine metabolism (adenine and guanine)

Question 4

Risk factors of gout?

Answer 4

male, obesity, excessive alcohol consumption (beer), hypertension, CKD, lead intoxication, advanced age, and drugs

Question 5

how to reduce risk fo gout?

Answer 5

avoid organ meats, high-fructose corn syrup and alcohol, sweets, lamb, pork

Question 6

medications that increase uric acid? (D,N,A,P,C,T,R)

Answer 6

diuretics, niacin, high dose aspirin, pyrazinamide, cyclosporine, tacrolimus, ribavirin

Question 7

drug class used to treat acute gout attack?

Answer 7

NSAID, systemic steroid, or oral colchicine

Question 8

What are patients at risk of if colchicine is used with: cyclosporin, diltiazem, verapamil, gemfibrozil and statin

Answer 8

myopathy and rhabdomyolysis

Question 9

MOA of allopruinol and febuxostat?

Answer 9

xanthine oxidase inhibitor

Question 10

MOA of lesinurad, probenecid, colchicine-probenecid?

Answer 10

uricosurics: inhibits reabsorption of uric acid in kidneys

Question 11

Colcry’s

Answer 11

clochicine

Question 12

NSAIDs used for gout

Answer 12

indomethacin, naproxen, sulindac, celecoxib or anyother

Question 13

Common steroids used for gout?

Answer 13

prednisone/prednisolone, methylprednisolone, triamcinolone

Question 14

Zyloprim, Aloprim

Answer 14

allopurinol

Question 15

Uloric

Answer 15

febuxostat

Question 16

Zurampic

Answer 16

lesinurad

Question 17

Krystexxa

Answer 17

pegloticase

Question 18

MOA of pegloticase?

Answer 18

recombinant uricase: converts uric acid to allantoin (inactive/h20 soluble metabolite)

Question 19

Drugs not to take with uloric

Answer 19

didanosine, mercaptopurine, azathioprine, pegloticase

Question 20

Why can’t prebenecid not be taken with aspririn?

Answer 20

probenecid will compete renally with salicylate

Question 21

What do you have to premedicate for pegloticase?

Answer 21

antihistamine, steroids

Question 22

Elitek

Answer 22

rasburicase

Question 23

what is rasburicase used for?

Answer 23

tumor lysis syndrome

Question 24

Allopurinol or febuxostat should not be used with?

Answer 24

meracptopurine and azathoprine

Question 25

pegloticase should not be used with these 2 drugs

Answer 25

allopurinol and febuxostat