Ch. 48 Dyslipidemia Flashcards
What is the formula for calculating LDL?
TC-HDL-(TG/5)
Desirable non-HDL?
<130
Desirable LDL-C?
<100
Desirable HDL -C?
> 40 in men and >50 in women
Desirable triglycerides?
<150
At what range do we treat patients for TG?
> 500 b/c increased risk for pancreatitis
Which organization that focus on Dyslipidmia?
ACC/AHA and NLA
What are the 4 statin benefit groups?
- with clinical ASCVD
- primary elevation of LDL-C >190 mg/dL
- with diabetes and 40-75 y/o with LDL-C 70-189 mg/dL
- 40-75 y/o with LDL-C 70-189 mg/dL and 10-year ASCVD risk > 7.5%
What are considered high intensity statin and % reduction?
- Atorvastatin 40-80
- Rosuvastatin 20-40
- 50%
What are considered moderate intensity statin and % reduction?
- atorvastatin 10-20
- rosuvastatin 5-10
- simvastatin 20-40
- pravastatin 40-80
- lovastatin 40
- fluvastatin XL 80
- pitavastatin 2-4 mg
- 30-49%
What are considered low intensity statin and % reduction?
- simvastatin 10
- pravastatin 10-20
- lovastatin 20
- fluvastatin 20-40
- pitavastatin 1 mg
- <30%
What is myopathy?
muscle weakness
What is myalgia?
muscle soreness
What is myositis?
muscle inflammation
Contraindication for statins?
active liver disease, pregnancy, breastfeeding, strong 3A4 inhibitors
MOA of statin?
HMG-CoA reductase inhibitors preventing the conversion of HMG-CoA to mevalonate
Which statins can be taken at any time of day?
crestor, lipitor, livalo, lescol XL, pravachol
Lipitor
Atorvastatin
Caduet
atorvastatin and amlodipine
Liptruzet
atorvastatin and ezetimibe
Lescol
fluvastatin
Mevacor, altoprev
lovastatin
Livalo
pitavastatin
pravachol
pravastatin
