Oncology/Hematology

Question 1

BRCA1 and BRCA2 increase the risk of what types of cancers?

Answer 1

breast and ovarian

Question 2

What seemingly unrelated disease increases the risk of ovarian cancer by 12%?

Answer 2

Lynch syndrome - hereditary nonpolyposis colon cancer

Question 3

Tumor markers

1. CA-125
2. AFP and hCG are elevated in the this less common classification of cancers?
3. Which type of testicular cancer produces the following?
   - AFP
   - hCG

Answer 3

1. Ovarian cancer
2. Germ cell cancers
3. nonseminoma

Question 4

When do you see smudge cells?

Answer 4

CLL

Question 5

When do you see teardrop shaped RBCs?

Answer 5

myelofibrosis

Question 6

What is a common complication of hereditary spherocytosis?

Answer 6

Gallstones

Question 7

reed-sternberg cells

Answer 7

hodgkins

Question 8

what is the hairy cell leukemia triad?

Answer 8

pancytopenia (50–75%),
splenomegaly (80–90%), and
inaspirable bone marrow (a dry tap; frequent).

Question 9

Methylmalonic acid (MMA) and homocysteine (HC) in B12 and folate deficiency

Answer 9

Both elevated for B12; HC only for folate deficiency

Question 10

When do you see the t(11:14) translocation?

Answer 10

With Mantle Cell lymphoma

Question 11

Auer rods

Answer 11

AML

Question 12

t (9;22)

Answer 12

Philadelphia chromosome

CML

Question 13

What is the most common leukemia in adults?

Answer 13

AML; CLL is the most common leukemia overall

Question 14

normal PT, elevated PTT, normal CBC, and elevated bleeding time

Answer 14

vWD

Question 15

Which blood malignancy doesn’t usually have splenomegaly?

Answer 15

AML