Allergy and Immunology

Question 1

How do you screen for a terminal complement deficiency?

Answer 1

Get a CH50 level

Question 2

What complements are used to follow disease activity in SLE?

Answer 2

C3, C4, and CH50

Question 3

Which complement is a good screen for complement deficiencies?

Answer 3

CH50

Question 4

Consider what complement deficiency in patients with early-onset SLE?

Answer 4

C2 deficiency

Question 5

To determine if you should step up therapy for asthma treatment, follow the rule of 2’s. What is that rule?

Answer 5

Step up therapy for any of the following:

• asthma symptoms during the day >2x/week
• night time awakenings >2x/month
• ED visits/admissions for asthma >2x/year

Question 6

Homozygous early complement deficiency (especially C1, C2, and C4) is associated with what?

Answer 6

recurrent bacterial sinopulmonary disease and development of SLE

Question 7

What are the dreaded organisms that can still thrive in immunosuppressed patients who are receiving very broad-spectrum antibiotics and antifungals?

Answer 7

Fusarium and Aspergillus

Question 8

1. beefy red nasal mucosa

2. pale blue or “boggy nasal mucosa

Answer 8

1. rhinitis medicamentosa

2. allergic rhinitis

Question 9

What should you suspect when you see more than one episode of invasive Neisseria?

Answer 9

terminal complement deficiency

Question 10

Which things can give “anaphylactoid” reactions?

Answer 10

nonsteroidal antiinflammatory drugs, ASA, radiocontrast agents, and rarely opiate medications