oncology & haematology

Question 1

Sickle cell disease inheritence

Answer 1

AR

Question 2

What is Thrombotic crisis

Answer 2

aka painful crisis, vaso-occlusive crisis

Question 3

Admission criteria for admission sickle cell

Answer 3

mild-mod pain + temp
well child mild-mod pain

Question 4

Crises in Sickle cell

Answer 4

1. thrombotic/ painful
2. acute chest syndrome
3. aplastic crises
4. sequestration crises

Question 5

Warfarin clotting profile Pt, aPTT, BT, Plt

Answer 5

pt prolonged, other normal

Question 6

Aspirin clotting profile Pt, aPTT, BT, Plt

Answer 6

BT prolonged others normal

Question 7

Heparin clotting profile Pt, aPTT, BT, Plt

Answer 7

PT often normal/ may be prolonged, aPTT prolonged

Question 8

DIC clotting profile Pt, aPTT, BT, Plt

Answer 8

Everything prolonged
Low -lt count
High FDP
Low fibrinogen

Question 9

tumour marker for ovarian cancer, pancreatic cancer, breast cancer

Answer 9

CA 125
CA 19-9
CA 15-3

Question 10

tumour marker for prostate cancer
hepatocellular carcinoma

Answer 10

PSA
AFP

Question 11

tumour marker for teratoma

Answer 11

AFP

Question 12

tumour marker for CRC

Answer 12

CEA

Question 13

tumour marker for melanoma, schwannomas

Answer 13

S-100

Question 14

tmour marker for small cell lung cancinnoma, gastric cancer, neuroblastoma

Answer 14

Bombesin

Question 15

Wells score for DVT

Answer 15

> 2 likely DVT: US within 4 hours if + anticoagulant, if - d-dimer test

<=1: d-dimer test within 4 hours, not for interim tx anti-coagulation. If - then DVT unlikely, if + then US carried out, if unable to Us within 4 hours give LMWH whilst waiting for Us