Meds

Question 1

SE Levothyroxine

Answer 1

hyperthyroidism
osteoporosis-> decreases BMD
worsening of angina
AF

Question 2

Indication + SE Carbimazole

Answer 2

Grave’s disease- anti-thyroid drug

AGRANULOCYTOSIS

Question 3

Mech of action statin + during what time of day do you take statin

Answer 3

inhibits HMG-CoA reductase rate limiting enzyme inhepatic cholesterol synthesis (dec intrinsic cholesterol synthesis).

Night as cholesterol synthesis occurs during night time

Question 4

monitoring statin

Answer 4

LFT every 3months and 24 months

Question 5

contraindication of statin

Answer 5

Macrolides: erythromycin + clarithromycin esp stimvastatin
increases risk of rhabdomyolysis/ myopathy

CYP3A4 inhibited by clarithromycin therefore increasing level of statin

Question 6

indication of statin, pri + sec intervention

Answer 6

indication:
ALL with CVD: IHD, stroke, TIA, PVD.
10 yr CV risk >10%
DM using QRISK 2, DM1: dx >10yr ago, >40yrs old, diabetic nephropathy

PRIMARY: atorvastatin 20mg
SECONDARY: 80mg OD following ACS

Question 7

salicylate overdose Lab results + sx

Answer 7

Resp alkalosis -> later metabolic acidosis

Sx: TINNITUS, hyperventilation, sweathing/ pyrexia, N+V

Question 8

salicylate mx

Answer 8

urinary alkalinisation w/ iv NaHCO3 inhances elimination of aspirin in urine

Haemodialysis indication:
serum conc >700mgL
Met acidosis resistant to tx
acute RF, pulmo oedema
seizure/coma

Question 9

hydroxychloroquine Monitoring

Answer 9

used in RA + SLE

visual acuity monitoring annually

Bulls’ eye retinopathy: severe + permanent visual loss