Cardiology Flashcards
Janesway Lesion
signs in infective endocarditis
- microemboli see on skins of palms and soles PAINLESS
Osler nodes
signs in infective endocarditis
- immunological reaction seen on tips of fingers and toes PAINFUL
stages of HTN
stage 1: clinic BP 140/90 or ABPM >135/85. <80yr QRISK >10%
stage 2: >160/100 or ABPM > 150/95
stage 3: SBP >180 or DBP 120
HTN mx steps <55 years old OR DM
step 1: ACEi/ AT2R ATG
step 2: A+C/ A+D (D- thiazide like diuretics- indapamide/ metolazone)
step 3: A+C+D
step 4: if K <= 4.5- add spironolatone; if K >4.5 add BB or alpha ATG
HTN mx steps >= 55year with no DM2 OR Black-African or Black-Carribean
step 1: Calcium
step 2: C+A or C+D
step 3: A+C+D
step 4: if K <= 4.5- add spironolatone; if K >4.5 add BB or alpha ATG
ECG changes anteroseptal MI
V1-V4
ECG changes anterolateral MI
V1-6, aVL
ECG changes Lateral MI
I, aVL +/- V5-6
ECG changes posterior MI
V1-3, reciprocal changes of STEMI seen horizontal ST dep, tall broad R waves, upright T waves, dominant R waves. Post infarction confirmed by STEMI and Q waves in posterior leads V7-V9
ECG leads circumflex artery
Lead I, V5-6 (lateral)
ECG leads Right coronary
II, III, aVF (INFERIOR)
ECG leads left anterior descending
V1- V4 ( ANTERIOR)
HF management line
1st line: BB + ACEi
2nd line: aldosterone ATG (spiro/eplerenone) +SGLT-2 inhibitor
3rd line: specialist: ivabradine, entresto, digoxin, hydralazine + nitrate, cardiac resyndronisation
CHA2DS2 VASc Score
CHF
HTN
Age >= 75
Diabetes
Stroke/TIA or Thromboemboslism
Vascular disease
Age 65-74
Sex Female
if >1 then anticoag long term
When to start tx for HTN
140//90 or ABPM 135/85
or <80yrs QRISK >10%
=> START Tx
target BP for HTN mx
<80yrs 140/90 or ABPM 135/85
>80yrs: 150/90 or 145/85
Normal QT interval make and female
Male 430msec
Female 50msec
Mx of angina stable
- Aspirin + statin
- GTN spray
- Beta blocker or ca2+ blocker
Ca ch blocker: verapamil or diltiazem-> rate limiting
Use amlodipine or mr mifedipine if using bb (dihydropyridine ) - Long acting nitrate/ivabradine/nicorandil/ranolatine if pt monotx cannot tolerate addition of ca ch blocker/ beta blocker
Don’t use bb and verapamil or diltiazem together as it increases risk of heart block
When to expect dressier sy
> 2 weeks
When to expect pericarditis post MI
48hrs
When to expect acute mitral regurg post mi- inferolat mi or rupture of papillary muscle post mi
3-5 days
2nd degree type 1 heart block aka, mx, ecg findings
Wenckebach, Mobil’s type 1
PR elongations until QRS drop beat occurs
Mx: nil mx needed unless symptomatic, pre-syncopated or syncopated, HoTN
2nd degree heart block type 2
Mobitz type 2
ECG: prolonged PR and drops QRS
Mx: pacemaker
Classification of AFib
Paroxysmal AF: lasts less than 7 days
Persistent AF: 1/12
Longstanding: >12 months
Absolute indication for DOAC in AFib
AFib with valvular disease
Stable AFib mx
<48hrs: if rate/rhythmn + heparinised electrical DC
If > 48 hours/ uncertain: rate and anticoagulation for minimum of 3 weeks
When to consider amiodarone inAFib
Esp if patient in HF
Scores used in AFib
CHA1DSC2 VASC RISK FACTOR
HASBLED
ORBIT
HASBLED SCORE
bleeding risk of DOAC in AFIB
HTN
Abnormal renal/liver function
Stroke
Bleeding hx
Labile INR
Elderly >65
Drugs/ alcohol
0-0-1 low risk
2 intermediate
>3 high risk
ORBIT SCORE
Bleeding risk DoAC in AFib
Older age >74
Reduced haemoglobin or anaemia
Bleeding hx
Insufficient kidney function
Tx with anti-plt
0-2 low risk
3 intermediate
>4 high risk
Which criteria used for infective endocarditis
Dukes criteria: 2 major or 1 major + 3 minor or 5 minor
BE TIMER
Blood culture positive >2 times 12 hours apart
Echocardiogram evidence of IE
Temp >38
Immunological phenomena: oslernode, Roth spots
Microbiological evidence + BC not meeting criteria
Embolic phenomenon- arterial embolism, septic embolism, conjunctival haemorrhage, painless skin lesion-Janeway
Risk factors: congenital heart condition or iv drug use
Which valve most affected by IE
Mitral valve
Tricuspid in iv drug users
Most common pathogen for IE, prosthetic valve
Staph aureus
Used to be strep Viridans
Prosthetic: coagulate negative strep epidermidis
Stages of HTN
Stage 1 : >140/90 or ABPM >135/85
Stage 2 : >160/100 or 150/95
Stage 3 or severe: SBP 180 OR DBP >120
When to expect rupture of papillary muscle due to MI
Severe complication of MI 3-5 days post
HoTN, pulmonary oedema
Early-mid systolic murmur
PCI timing in MI
PCI:
STEMI sx within 12 hours and PCI can be offered within 120min- aspirin + clopidogrel
If sx within 12 hours but primary PCI x offered within 120min then start fibrinolysis (fondaprinux)
Repeat ECG with ST elevation not resolving needs rescue PCI
DOAC & anti-latest post MI
If post ACS/ PCI with Bg AFib
DAPT and 1 DoAC for 1-6months then 1 anti platelet and 1 anticoagulant
If stable CVD with indication for DoAC eg. AFib then anticoagulant monotx without anti platelet
Secondary prevention after ACS
Statin, beta blocker, ACEi
Pericarditis Ix esp ECG Findings
ECG: global widespread ST changes elevation (saddle shaped) with PR Depression
TTE: check pericardial effusion
Labs: high trip, high inflammatory markers, high ESR
Mx pericarditis
NSAIDS + Colchicine 1st line for idiopathic/ viral cause
+/- corticosteroid
Cardiac tamponade sx, whiat happens to SBP & ECG
Becks triad: HoTN, elevated JVP, muffled heart sound
Tachycardia
Oculus’s paradoxes deacrease in SBP >10mmHg during inspiration
ECG small QRS complexes
Electric alternates - QRS complexes different height
Scores used in PE
Wells criteria- likely PE calculation
PESI- PE severity index
ORBIT score for bleeding risk
PE Ix esp ECg
CTPA> V/Q scan
When to use VQ scan: alternative dx of PE, renal impairment. Mismatch V/Q: old PE, AV malformation/ vasculitis/ COPD
D-dimer- use age adjusted d-dimer
ECG S1Q3T3, RBBB, RT AXIS DEVIATION
Duration of DOAC IN PE
Unprovoked use for 6months and review using ORBIT
Provoked for 3months
Diastolic murmur
Aortic and pulmonary regurgitation
Mitral and tricuspid stenosis
Which gives continuous murmur
Patent ductus arterosus
When to consider surgical mx for aortic valve stenosis
When valve gradient >40mmHg and features of LV systolic dysfunction
Biological vs prosthetic valve replacement
Biological: for older patient >65 as risk of calcification over time. Long term anticoagulant not usually needed
Mechanical increased risk of thrombosis- long term anticoagulant needed. Warfarin used in preference to DOAC
Aortic dissection classification
Stanford and DeBakey
Stanford:
A- asc aorta , 2/3 of cases
B- describe aortal distal left subclavian 1/3 cases
DeBakey
Type I: asc aorta to at least aortic arch and possibly beyond dismally
Type II: asc aorta only
Type III: descending aorta
Aortic dissection Ix
CXR: widened mediastinum
CT-Angio: stable pt , able to mx surgically
TOE: unstable pt risky to take to CT scanner
Mx Aortic dissection
Type A: surgical mx, control SBP 100-120mmHg
Inheritance of hypertrophic obstructive cardiomyopathy
AD
Most common cause of sudden cardiac death in young pts
Mx of hypertrophic obstructive cardiomyopathy
ABCDE
amiodarone, beatable/ verapamil, cardioverter Defib
Dual chamber pacemaker, endocarditis prophylaxis
Definition of postural hypotension
Standing BP falls
SBP>20mmHg
DBP: >10mmHg
Or SBP<90mmHg