Oncology Flashcards
Colon Cancer, what is the standard chemo regimen? Think IIB to IV
FOLFOX: 5 Flurouracil, Leucovorin, and Oxaliplatin with oral capecitabine
Rectal Cancer has a high recurrence rate, what is normally done?
Radiation
Stage 1 breast cancer, does it require further imaging?
No
Large Cell Lymphoma, what routine testing is usually done for risk stratification?
Lactate Dehydrogenase (LDH), bone biopsy is rarely done.
Cervical Cancer Stage III, what treatment should be done?
Cisplatin and Radiation Therapy
A patient with CLL, repeat respiratory infections, repeat IV antibiotics, hospitalizations, what should be given?
IVIG, increase antibody concentration
Hepatocellular Carcinoma treatment for a Child-Turcotte-Pugh score < 7, is what?
Sorafenib
What type of thyroid cancer has biphasic spindle and giant cell tumor?
Anaplastic Thyroid Cancer, BRAF V600 mutation
What type of thyroid cancer has large cells with ground glass cytoplasm and prominent nucleoli with clefts, grooves, and holes due to intranuclear cytoplasmic inclusions, some call “Orphan Annie Eyes”?
Papillary Thyroid Cancer
Colon Cancer Stage I-IIA, what is the treatment?
Capecitabine or 5-FU/leucovorin or Surgery without treatment
What does FOLFOX stand for? Colon Cancer IIB to IV
Oxaliplatin + leucovorin + 5 FU + folinic acid (calcium)
What is a IIB to IV Colon Cancer Regimen?
Not FOLFOX
FOLFIRI -> Irinotecan, leuocovorin, 5-FU
Patient has AML with PML-RARA and FLT3-ITD mutations, what is a good chemo starting point?
Cytarabine plus daunorubicin
What foot stress fracture area is concerning for malunion healing? This should be a quick referral to orthopedic surgery/podiatry
Proximal fifth metatarsal shaft fracture
Patient’s using bisphosphonates should have a drug holiday of how long with the following routes?
Oral?
IV?
Oral Bisphosphonates can have a holiday after 5 years
IV Bisphosphonates can have a holiday after 3 years
Non-hodgkin lymphoma, advanced stage follicular lymphoma, what is the treatment?
Rituximab + chemotherapy or lenalidomide
CLL is diagnosed how?
CD19, CD20, and CD 23, co-expression of CD-5. Bone Marrow biopsy is not needed.
CLL via pathology slide has what?
Smudge Cells and elevated Basophils
Hairy Cell Leukemia has what with bone marrow?
Dry Tap
What is the first line treatment for hairy cell leukemia?
Hairy Cell Leukemia may have BRAF V600E mutation, as well
Pentostatin or Cladribine
Relapses can have Rituximab
BRAF inhibitor -> Vemurafenib
Diffuse B cell Lymphoma has what elevated gene expression?
BCL6
Advanced-stage diffuse large B-cell lymphoma has what standard treatment regimen?
Rituximab + Cyclophosphamide + Doxorubicin + Vincristine + Prednisone (R-CHOP regimen)
