Landmark trials Flashcards
The authors concluded that “Early goal-directed therapy provides significant benefits with respect to outcome in patients with severe sepsis and septic shock.”
RIVERS trail, NEJM 2021
The authors concluded that ” In a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes.”
PROCESS trail, NEJM 2014
The authors concluded that “Targeting a mean arterial pressure of 80 to 85 mm Hg, as compared with 65 to 70 mm Hg, in patients with septic shock undergoing resuscitation did not result in significant differences in mortality at either 28 or 90 days.”
SEPSISSPAM, NEJM 2014
The authors concluded that “Although there was no significant difference in the rate of death between patients with shock who were treated with dopamine as the first-line vasopressor agent and those who were treated with norepinephrine, the use of dopamine was associated with a greater number of adverse events.”
SOAP II, NEJM 2010
The authors concluded that “Among patients with septic shock, mortality at 90 days and rates of ischemic events and use of life support were similar among those assigned to blood transfusion at a higher hemoglobin threshold and those assigned to blood transfusion at a lower threshold; the latter group received fewer transfusions.”
TRISS, NEJM 2014
The authors concluded that “Among critically ill adults, the use of balanced crystalloids for intravenous fluid administration resulted in a lower rate of the composite outcome of death from any cause, new renal-replacement therapy, or persistent renal dysfunction than the use of saline.”
SMART, NEJM 2018
The authors concluded that ” In this large, international, randomized trial, we found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg per deciliter.”
NICE Sugar, NEJM 2009
The authors concluded that ”In patients who are receiving mechanical ventilation, daily interruption of sedative-drug infusions decreases the duration of mechanical ventilation and the length of stay in the intensive care unit.“
Daily Interruption of Sedation, NEJM 2000
In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome, NEJM 2000
The authors concluded that “In patients with severe ARDS, early application of prolonged prone-positioning sessions significantly decreased 28-day and 90-day mortality.”
PROSEVA, NEJM 2013
The authors concluded that “Among patients with moderate-to-severe ARDS who were treated with a strategy involving a high PEEP, there was no significant difference in mortality at 90 days between patients who received an early and continuous cisatracurium infusion and those who were treated with a usual-care approach with lighter sedation targets.”
Rose Trial, NEJM 2019
The authors concluded that “In this trial, subclavian-vein catheterization was associated with a lower risk of bloodstream infection and symptomatic thrombosis and a higher risk of pneumothorax than jugular-vein or femoral-vein catheterization.”
3SITES Trial, NEJM, 2015
The authors concluded that “An evidence-based intervention resulted in a large and sustained reduction (up to 66%) in rates of catheter-related bloodstream infection that was maintained throughout the 18-month study period.”
CLABSI Trial, NEJM 2006
Trial that showed chlorthalidone helped CKD and HTN at stage 2 and 3, after 12 weeks vs. placebo?
CLICK trail, NEJM 2021
