oncogenes/tumor suppressor genes Flashcards

1
Q

ALK

A

Oncogene
gene product: Receptor tyrosine kinase
associated neoplasm: Lung adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

BCR-ABL

A

Oncogene
Tyrosine kinase
CML, ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

BCL-2

A

Oncogene
Antiapoptotic molecule (inhibits apoptosis)
Follicular and diffuse large B cell lymphomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

BRAF

A

Oncogene
Serine/threonine kinase
Melanoma, non-Hodgkin lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

c-KIT

A

Oncogene
Cytokine receptor
Gastrointestinal stromal tumor (GIST)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

c-MYC

A

Oncogene
Transcription factor
Burkitt lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

HER2/neu (c-erbB2)

A

Oncogene
Tyrosine kinase
Breast and gastric carcinomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

JAK2

A

Oncogene
Tyrosine kinase
Chronic myeloproliferative disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

KRAS

A

Oncogene
GTPase
Colon cancer, lung cancer, pancreatic cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MYCL1

A

Oncogene
Transcription factor
Lung tumor
L=Lung

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MYCN

A

Oncogene
Transcription factor
Neuroblastoma
N=Neuroblastoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

RET

A

Oncogene
Tyrosine kinase
MEN 2A and 2B, medullary thyroid cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

APC

A
Tumor suppressor gene
Colorectal cancer (assoc. w. FAP)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

BRCA1/BRCA2

A

Tumor suppressor gene
associated condition: Breast and ovarian cancer
gene product: DNA repair protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CDKN2A

A

Tumor suppressor gene
Melanoma, pancreatic cancer
p16, blocks G1–>S phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

DCC

A

Tumor suppressor gene
Colon cancer
DCC- Deleted in Colon Cancer

17
Q

DPC4/SMAD4

A

Tumor suppressor gene
Pancreatic cancer
DPC—Deleted in Pancreatic Cancer

18
Q

MEN1

A

Tumor suppressor gene
MEN 1
Menin

19
Q

NF1

A

Tumor suppressor gene
NeuroFibromatosis type 1
Ras GTPase activating protein (neurofibromin)

20
Q

NF2

A

Tumor suppressor gene
NeuroFibromatosis type 2
Merlin (schwannomin) protein

21
Q

PTEN

A

Tumor suppressor gene

Breast cancer, prostate cancer, endometrial cancer

22
Q

Rb

A

Tumor suppressor gene
Retinoblastoma, osteosarcoma
Inhibits E2F; blocks G1–>S phase

23
Q

TP53

A

Tumor suppressor gene
Most human cancers, Li-Fraumeni syndrome
p53, activates p21, blocks G1–>S phase

24
Q

TSC1

A

Tumor suppressor gene
Tuberous sclerosis
Hamatin protein

25
Q

TSC2

A

Tumor suppressor gene
Tuberous sclerosis
Tuberin protein

26
Q

VHL

A

Tumor suppressor gene
von Hippel-Lindau disease, renal cell carcinoma
Inhibits hypoxia inducible factor 1a

27
Q

WT1/WT2

A
Tumor suppressor gene
Wilms Tumor (nephroblastoma)