oncogenes/tumor suppressor genes

Question 1

ALK

Answer 1

Oncogene
gene product: Receptor tyrosine kinase
associated neoplasm: Lung adenocarcinoma

Question 2

BCR-ABL

Answer 2

Oncogene
Tyrosine kinase
CML, ALL

Question 3

BCL-2

Answer 3

Oncogene
Antiapoptotic molecule (inhibits apoptosis)
Follicular and diffuse large B cell lymphomas

Question 4

BRAF

Answer 4

Oncogene
Serine/threonine kinase
Melanoma, non-Hodgkin lymphoma

Question 5

c-KIT

Answer 5

Oncogene
Cytokine receptor
Gastrointestinal stromal tumor (GIST)

Question 6

c-MYC

Answer 6

Oncogene
Transcription factor
Burkitt lymphoma

Question 7

HER2/neu (c-erbB2)

Answer 7

Oncogene
Tyrosine kinase
Breast and gastric carcinomas

Question 8

JAK2

Answer 8

Oncogene
Tyrosine kinase
Chronic myeloproliferative disorders

Question 9

KRAS

Answer 9

Oncogene
GTPase
Colon cancer, lung cancer, pancreatic cancer

Question 10

MYCL1

Answer 10

Oncogene
Transcription factor
Lung tumor
L=Lung

Question 11

MYCN

Answer 11

Oncogene
Transcription factor
Neuroblastoma
N=Neuroblastoma

Question 12

RET

Answer 12

Oncogene
Tyrosine kinase
MEN 2A and 2B, medullary thyroid cancer

Question 13

APC

Answer 13

Tumor suppressor gene
Colorectal cancer (assoc. w. FAP)

Question 14

BRCA1/BRCA2

Answer 14

Tumor suppressor gene
associated condition: Breast and ovarian cancer
gene product: DNA repair protein

Question 15

CDKN2A

Answer 15

Tumor suppressor gene
Melanoma, pancreatic cancer
p16, blocks G1–>S phase

Question 16

DCC

Answer 16

Tumor suppressor gene
Colon cancer
DCC- Deleted in Colon Cancer

Question 17

DPC4/SMAD4

Answer 17

Tumor suppressor gene
Pancreatic cancer
DPC—Deleted in Pancreatic Cancer

Question 18

MEN1

Answer 18

Tumor suppressor gene
MEN 1
Menin

Question 19

NF1

Answer 19

Tumor suppressor gene
NeuroFibromatosis type 1
Ras GTPase activating protein (neurofibromin)

Question 20

NF2

Answer 20

Tumor suppressor gene
NeuroFibromatosis type 2
Merlin (schwannomin) protein

Question 21

PTEN

Answer 21

Tumor suppressor gene

Breast cancer, prostate cancer, endometrial cancer

Question 22

Rb

Answer 22

Tumor suppressor gene
Retinoblastoma, osteosarcoma
Inhibits E2F; blocks G1–>S phase

Question 23

TP53

Answer 23

Tumor suppressor gene
Most human cancers, Li-Fraumeni syndrome
p53, activates p21, blocks G1–>S phase

Question 24

TSC1

Answer 24

Tumor suppressor gene
Tuberous sclerosis
Hamatin protein

Question 25

TSC2

Answer 25

Tumor suppressor gene
Tuberous sclerosis
Tuberin protein

Question 26

VHL

Answer 26

Tumor suppressor gene
von Hippel-Lindau disease, renal cell carcinoma
Inhibits hypoxia inducible factor 1a

Question 27

WT1/WT2

Answer 27

Tumor suppressor gene
Wilms Tumor (nephroblastoma)