oncogenes/tumor suppressor genes Flashcards
ALK
Oncogene
gene product: Receptor tyrosine kinase
associated neoplasm: Lung adenocarcinoma
BCR-ABL
Oncogene
Tyrosine kinase
CML, ALL
BCL-2
Oncogene
Antiapoptotic molecule (inhibits apoptosis)
Follicular and diffuse large B cell lymphomas
BRAF
Oncogene
Serine/threonine kinase
Melanoma, non-Hodgkin lymphoma
c-KIT
Oncogene
Cytokine receptor
Gastrointestinal stromal tumor (GIST)
c-MYC
Oncogene
Transcription factor
Burkitt lymphoma
HER2/neu (c-erbB2)
Oncogene
Tyrosine kinase
Breast and gastric carcinomas
JAK2
Oncogene
Tyrosine kinase
Chronic myeloproliferative disorders
KRAS
Oncogene
GTPase
Colon cancer, lung cancer, pancreatic cancer
MYCL1
Oncogene
Transcription factor
Lung tumor
L=Lung
MYCN
Oncogene
Transcription factor
Neuroblastoma
N=Neuroblastoma
RET
Oncogene
Tyrosine kinase
MEN 2A and 2B, medullary thyroid cancer
APC
Tumor suppressor gene Colorectal cancer (assoc. w. FAP)
BRCA1/BRCA2
Tumor suppressor gene
associated condition: Breast and ovarian cancer
gene product: DNA repair protein
CDKN2A
Tumor suppressor gene
Melanoma, pancreatic cancer
p16, blocks G1–>S phase