Oncogenes and tumour suppressor genes

Question 1

What are oncogenes?

Answer 1

Cancer promoting genes
Gain of function results in increased risk of cancer

Question 2

What are tumour suppressor genes?

Answer 2

Restrict or repress cellular proliferation
Loss of function results in increased risk of cancer

Question 3

ABL

Answer 3

Oncogene
CML

Question 4

c-MYC

Answer 4

Oncogene
Burkitt’s lymphoma

Question 5

n-MYC

Answer 5

Oncogene
Neuroblastoma

Question 6

BCL-2

Answer 6

Oncogene
Follicular lymphoma

Question 7

RET

Answer 7

Oncogene
Multiple endocrine neoplasia type 2 and 3

Question 8

RAS

Answer 8

Oncogene
Pancreatic cancer

Question 9

HER2

Answer 9

Oncogene
Breast and ovarian cancer

Question 10

APC

Answer 10

Tumour suppressor gene
Colorectal cancer

Question 11

BRCA 1 and 2

Answer 11

Tumour suppressor gene
Breast and ovarian cancer
Pancreatic cancer
BRCA 2 - Prostate cancer in men

Question 12

NF1

Answer 12

Tumour suppressor gene
Neurofibromatosis

Question 13

Rb

Answer 13

Tumour suppressor gene
Retinoblastoma

Question 14

WT1

Answer 14

Tumour suppressor gene
Wilm’s tumour

Question 15

Multiple tumour suppressor 1(p16)

Answer 15

Tumoru suppressor
Melanoma

Question 16

p53

Answer 16

Tumour suppressor gene