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Physiology MRCP > Cytokines > Flashcards

Cytokines Flashcards

1
Q

What is the main source of IL1?

A

Macrophages

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2
Q

What is the function of IL1?

A

Acute inflammation
Induces fever
Vasodilation and increases vascular permeability (ie causes shock in sepsis)

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3
Q

What is the mechanism of IL1?

A

Costimulator of B and T cells

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4
Q

What is the main source of IL2?

A

Th1 cells

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5
Q

What is the function of IL2?

A

Stimulated growth and differentiation of T cell response

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6
Q

What is the main source of IL3?

A

Activated T helper cells

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7
Q

What is the function of IL3?

A

Stimulated differentiation and proliferation of myeloid progenitor cells

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8
Q

What is the main source of IL4?

A

Th2 cells

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9
Q

What is the function of IL4?

A

Stimulated proliferation and differentiation of B cells

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10
Q

What is the main source of IL5?

A

Th2 cells

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11
Q

What is the function of IL5?

A

Stimulate production of eosinophils

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12
Q

What are the main sources of IL6?

A

Macrophages
Th2 cells

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13
Q

What is the function of IL6?

A

Stimulated differentiation of B cells
Induces fever

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14
Q

What is the main source of IL8?

A

Macrophages

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15
Q

What is the function of IL8?

A

Neutrophil chemotaxis

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16
Q

What is the main source of IL10?

A

Th2 cells

17
Q

What is the function of IL10?

A

Inhibits Th1 cytokine production
Anti-inflammatory cytokine

18
Q

What are the main sources of IL12?

A

Dendritic cells
Macrophages
B cells

19
Q

What is the function of IL12?

A

Activates NK cells
Stimulated differentiation of naive T cells to Th1 cells

20
Q

What is the main source of tumour necrosis factor a (TNFa)?

A

Macrophages

21
Q

What are the functions of TNFa?

A

Induces fever
Neutrophil chemotaxis

22
Q

What is the main source of interferon gamma?

A

NK cells

23
Q

What is the function of interferon gamma?

A

Activates macrophages

24
Q

What is the source of interferon a?

A

Leucocytes

25
Q

What is the function of interferon alpha?

A

Antiviral action

26
Q

What is the source of interferon beta?

A

Fibroblasts

27
Q

What conditions is interferon alpha useful in?

A

Hep B and C
Kaposi’s sarcoma
Metastatic renal cell cancer
Hairy cell leukaemia

28
Q

What is the function of interferon beta?

A

Antiviral action

29
Q

What condition is interferon beta useful in?

A

Relapsing remitting MS

30
Q

What is the source of interferon gamma?

A

Natural killer cells and T helper cells

31
Q

What is the function of interferon gamma?

A

Immunomodulation, particularly macrophage activation

Physiology MRCP (19 decks)

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