Cytokines Flashcards
What is the main source of IL1?
Macrophages
What is the function of IL1?
Acute inflammation
Induces fever
Vasodilation and increases vascular permeability (ie causes shock in sepsis)
What is the mechanism of IL1?
Costimulator of B and T cells
What is the main source of IL2?
Th1 cells
What is the function of IL2?
Stimulated growth and differentiation of T cell response
What is the main source of IL3?
Activated T helper cells
What is the function of IL3?
Stimulated differentiation and proliferation of myeloid progenitor cells
What is the main source of IL4?
Th2 cells
What is the function of IL4?
Stimulated proliferation and differentiation of B cells
What is the main source of IL5?
Th2 cells
What is the function of IL5?
Stimulate production of eosinophils
What are the main sources of IL6?
Macrophages
Th2 cells
What is the function of IL6?
Stimulated differentiation of B cells
Induces fever
What is the main source of IL8?
Macrophages
What is the function of IL8?
Neutrophil chemotaxis
What is the main source of IL10?
Th2 cells
What is the function of IL10?
Inhibits Th1 cytokine production
Anti-inflammatory cytokine
What are the main sources of IL12?
Dendritic cells
Macrophages
B cells
What is the function of IL12?
Activates NK cells
Stimulated differentiation of naive T cells to Th1 cells
What is the main source of tumour necrosis factor a (TNFa)?
Macrophages
What are the functions of TNFa?
Induces fever
Neutrophil chemotaxis
What is the main source of interferon gamma?
NK cells
What is the function of interferon gamma?
Activates macrophages
What is the source of interferon a?
Leucocytes
What is the function of interferon alpha?
Antiviral action
What is the source of interferon beta?
Fibroblasts
What conditions is interferon alpha useful in?
Hep B and C
Kaposi’s sarcoma
Metastatic renal cell cancer
Hairy cell leukaemia
What is the function of interferon beta?
Antiviral action
What condition is interferon beta useful in?
Relapsing remitting MS
