Olanzapine Oral Dispersable Flashcards

1
Q

Olanzapine Intro

A
  • Olanzapine is a second generation antipsychotic agent that acts on multiple receptors (incl. serotonin and dopamine receptors), resulting in sedation
  • Onset of effect usually ~ 10 mins.
  • Use of a sedative agent should never be considered routine. Have a high threshold to offer or administer.
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2
Q

Olanzapine Indications

A
  • Disturbed and Abnormal Behaviour (RASS 1 ~ 3) if considered appropriate where risk to safety is evident and de-escalation has not been effective
  • Patient is able to tolerate or self-administer an oral wafer
  • Preferred first line sedation agent in frail patients and those with Dementia
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3
Q

Olanzapine Contraindications

A
  • Known Allergy
  • Known Parkinsons Disease
  • Age < 6 years of age
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4
Q

Olanzapine Precautions / Notes

A
  • Address organic causes for behavioural presentations at all times- eg. CVA, TBI, Hypoxia, Hypoglycaemia, etc
  • Dementia patients – apply caution. Use lower doses
  • Oral dispersible tablet may be dissolved in water (may slightly delay onset of action but still preferable in non-emergent cases)
  • ‘Agitated or Excited Delirium’, ‘Acute Behavioural Disturbance’ and ‘Drug Induced Psychosis’ are some alternative terms that may be used by other agencies
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5
Q

Olanzapine Special Considerations (Side Effects)

A
  • Extrapyramidal effects / Dyskinesia
  • Increased falls risk
  • Hypotension – Apply monitoring as soon as practicable
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