Olanzapine Oral Dispersable Flashcards
1
Q
Olanzapine Intro
A
- Olanzapine is a second generation antipsychotic agent that acts on multiple receptors (incl. serotonin and dopamine receptors), resulting in sedation
- Onset of effect usually ~ 10 mins.
- Use of a sedative agent should never be considered routine. Have a high threshold to offer or administer.
2
Q
Olanzapine Indications
A
- Disturbed and Abnormal Behaviour (RASS 1 ~ 3) if considered appropriate where risk to safety is evident and de-escalation has not been effective
- Patient is able to tolerate or self-administer an oral wafer
- Preferred first line sedation agent in frail patients and those with Dementia
3
Q
Olanzapine Contraindications
A
- Known Allergy
- Known Parkinsons Disease
- Age < 6 years of age
4
Q
Olanzapine Precautions / Notes
A
- Address organic causes for behavioural presentations at all times- eg. CVA, TBI, Hypoxia, Hypoglycaemia, etc
- Dementia patients – apply caution. Use lower doses
- Oral dispersible tablet may be dissolved in water (may slightly delay onset of action but still preferable in non-emergent cases)
- ‘Agitated or Excited Delirium’, ‘Acute Behavioural Disturbance’ and ‘Drug Induced Psychosis’ are some alternative terms that may be used by other agencies
5
Q
Olanzapine Special Considerations (Side Effects)
A
- Extrapyramidal effects / Dyskinesia
- Increased falls risk
- Hypotension – Apply monitoring as soon as practicable