Olanzapine Flashcards

1
Q

Mode of action

A

Atypical antipsychotic

  • antagonist at multiple receptor sites
  • particularly serotonin (5-HT), dopamine and histamine
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2
Q

Indications

A

Mild agitation

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3
Q

Contras

A

NIL

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4
Q

Precautions

A
  • May be less effective if pt agitation is due to drug intoxication (especially stimulants) or alcohol withdrawal. Benzodiazepines are considered first-line agents in these pt’s
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5
Q

Significant interactions

A

Sedative medications / alcohol

  • over sedation due to synergistic effects
  • avoid combination where possible
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6
Q

Adverse effects

A

CNS:

  • Sedation
  • dizziness

Other:
- extrapyramidal symptoms and QT prolongation are unlikely when administered at the approved doses

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7
Q

Administration advice

A

Route of administration:
- Oral ODT dissolved in mouth and then swallowed

Onset of action:
- 15 mins

Duration of action:
- 12 - 24 hrs

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8
Q

Pregnancy and breastfeeding

A

Pregnancy:

  • limited evidence
  • administer only if benefit outweighs risk

Breastfeeding:
- considered safe to use

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9
Q

Special notes

A
  • Pt’s < 16 yrs consult with receiving hospital
  • must self administer
  • restricted medication

Similar name and presentation to ondansetron
- extra care must be taken prior to administration

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10
Q

Agitated Patient

A

Mild agitation - SAT score +1

Adult
- 10 mg ODT

< 60 kg / frail / elderly / sedating drug / alcohol
- 5 mg ODT

Repeat initial dose after 20 mins if pt remains mildly agitated

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