Misoprostol Flashcards

1
Q

Presentation

A

200 mcg tablet

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2
Q

Pharmacology

A

Synthetic prostaglandin

Actions:
- Enhance uterine contractions

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3
Q

Metabolism

A
  • Converted to active metabolite misoprostol acid in the blood
  • metabolised in the tissues and excreted by the kidneys
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4
Q

Indications

A

PPH (Primary postpartum haemorrhage)

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5
Q

Contras

A
  • Allergy to prostaglandins

- Exclude multiple pregnancy before drug administration

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6
Q

Precautions

A

History of asthma

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7
Q

Route of administration

A

Oral

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8
Q

Side effects

A
  • Hyperpyrexia
  • Shivering
  • Abdominal pain
  • Diarrhoea
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9
Q

Special notes

A

Side effects are more likely with > 600 mcg oral dose

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10
Q

Oral effects

A

Onset: 8-10 mins
Peak: n/a
Duration: 2-3 hrs

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11
Q

PPH

A

Fundus remains not firm (in spite of previous Mx)

- 800 mcg oral

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