oesophageal disorders Flashcards

1
Q

How is food moved through oesophagus

A

Oesophageal peristalsis produced by the circular muscles

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2
Q

What innervates the oesophageal peristalsis and relaxation of the lower oesophageal sphincter (LOS)

A

Vagus nerve

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3
Q

Describe how heartburn might feel

A

Retrosternal heartburn or discomfort

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4
Q

What causes heartburn

A

acid reflux

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5
Q

What does persistent reflux and heartburn lead to

A

Gastro-oesophageal reflux disease (GORD)

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6
Q

What is dysphagia

A

Difficulty swallowing foods

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7
Q

What can cause dysphagia

A

Benign stricture
Malignant stricture - oesophageal cancer
Motility disorder (achalasia)

Stricture is most common cause

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8
Q

How is oesophageal disease investigated

A

Endoscopy when patient has ALARM features

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9
Q

Describe hypermotility of oesophagus

A

Diffuse oesophageal spasm - corkscrew appearance on Ba swallow

Severe episodic chest pain with or without dysphagia

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10
Q

What is the treatment for hyper-motility of oesophagus

A

Smooth muscle relaxants

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11
Q

What is achalasia

A

Functional loss of the myenteric plexus ganglion in the distal oesophagus and lower oesophageal sphincter

Failure of LOS to relax which causes distal obstruction of oesophagus

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12
Q

What is the presentation of achalasia

A

Progressive dysphagia for solids and liquids
Weight loss
Chest pain - sometimes
Regurgitation and chest infection

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13
Q

What is the treatment of achalasia

A

Nitrates, calcium channel blockers

Botulinum toxin pneumatic balloon dilation

Surgical - myotomy

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14
Q

What does achalasia increase the risk of

A

Squamos cell oesophageal carcinoma

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15
Q

What are the symptoms of GORD

A

Heart burn
Cough
Water brash
Sleep disturbance

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16
Q

Risk factors for GORD

A

Pregnancy, obesity, drugs lowering LOS pressure, smoking, alcoholism, hypomotility

17
Q

Who most commonly has GORD

A

Men > women

White > black > asian

18
Q

How is GORD diagnosed

A

clinically from history or endoscopy if ALARM features suggest malignancy

19
Q

What is hiatus hernia

A

Herniation of the stomach up into the chest through the oesophagus

20
Q

What are the 2 types of hiatus hernia

A

Sliding and para-oesophageal

21
Q

Which type of hiatus is worse

A

Para-oesophageal since the hiatus hernia is at risk of incarceration due to becoming trapped in the oesophagus

22
Q

What happens in GORD

A

mucosa is exposed to the acid-pepsin and bile which causes cell loss and inflammation

23
Q

Describe Barret’s oesophagus

A

Change from squamos to mucin secreting columnar

24
Q

What is the treatment of barret’s oesophagus

A

Endoscopic mucosal resection -sucking up the abnormal area into a cap on the scope and then a rubber band is fired into the area which lifts the abnormal area of the oesophageal wall. Then resection can be done by a smear on the endoscope

25
Q

What is the treatment of GORD

A

Lifestyle changes
Alginates - gaviscone
H2RA - ranitidine
PPI - omeprazole

26
Q

What is the presentation of oesophageal cancer

A

Progressive dysphagia
Anorexia and weight loss
Chest pain
Cough
Pneumonia
Haematemesis

27
Q

Where does squamos carcinoma of the oesophagus occur

A

upper 2/3

28
Q

Where does adenocarcinoma occur in oesophagus

A

Distal 1/3 of oesophagus

29
Q

Who is most at risk for adenocarcinoma

A

Obese male who are middle age and white

30
Q

How is oesophageal cancer diagnosed

A

Endoscopy and biopsy

31
Q

What is the treatment for oesophageal cancer

A

Only potential cure is surgical oesophagectomy with adjuvant or neoadjuvant chemotherapy - this is only given to localised disease cases who are under 70 and low co-morbidities

Symptom palliative care is often priority

32
Q

What is the presentation of eosinophilic oesophagitis

A

Dysphagia and food bolus obstruction

33
Q

What is the treatment for eosinophilic oesophagitis

A

Oral corticostreroids , dietary elimination or endoscopic dilatation