liver symposium Flashcards
which hepatitis infections are enteric - transmitted by contact or digestion
A and E
Which hepatitis viruses are parenteral viruses - transmitted through skin penetration
B,C and D
Which hepatitis viruses are self limiting
A and E
Which hepatitis lead to chronic disease
B,C and D
Which hepatitis lead to cirrhosis
B and C
What does IgM show in Hep A
If the patient currently has the disease
What does IgG show in patient with hepatitis A
if the patient has had it in the past
What age group commonly gets Hep A
5-14 years old
Who is given the HAV - Hep A vaccine
- Travellers
- Patients with chronic liver disease
- haemophiliacs - cant clot blood
- occupational exposure
- Gay men
What does positive HBsAG mean
Active infection
What does HBeAg positive mean
Chronic active
What does HBeAg negative mean
Chronic inactive
What does Anti-HBs positive mean
Cleared the infection before or is vaccinated
What does IgM anti-HBc mean
Acute infection
What does IgG anti HBC mean
Chronic infection
What is the most common oral therapy used for hepatitis B
Tenofovir - side effect of renal toxicity
Describe hep C virus
Most asymptomatic until cirrhosis with normal LFT’s
Describe Hep D virus
Co-infection or super infection with HBV - hep B virus
Very resistant to treatment
What is the commonest cause of acute hepatitis in grampian
Hep E
Describe the NAFLD score
Age >45 high risk
Diabetes - high risk
BMI>30 high risk
AST:ALT>1 - high risk
Platelets <150 high risk
Albumin <34 high risk
What is the treatment for NAFLD - non-alcoholic fatty liver disease
Diet and weight reduction
Excercis
Metformin
GLP1 analogues - liraglutide
Vitamin E
How is autoimmune hepatitis diagnosed
Liver biopsy
High IgG
What is the treatment for autoimmune hepatitis
Long term azathioprine - immunosupressant
Describe features of primary biliary cholangitis
Female mainly
IgM elevates
Anti-mitochondrial antibody positive (AMA)
Intrahepatic bile duct involved
