Obstructive Lung Diseases Flashcards
What is the main problem in obstructive pulmonary disease?
Limitation of airflow in expiration
Increase in resistance due to partial or complete obstruction
How is the FEV1/FVC ratio affected in obstructive diseases?
FEV1 is reduced
What are the four main obstructive pulmonary diseases?
Asthma
Chronic Bronchitis
Emphysema
Bronchiectasis
Which of the obstructive pulmonary diseases are known as COPD?
Chronic bronchitis
Emphysema
Asthma
What is the main problem? Where are how does the obstruction occur?
Intermittent and reversible airway obstruction
Due to a hyperresponsive tracheobronchial tree
Asthma
Symptoms
Wheezing
Breathlessness
Chest tightness
Cough
Why have asthma rates increased dramatically in recent years?
Hygiene hypothesis is one idea (eradication of infections leads to alteration of immune homeostasis)
What are some stimuli that could induce asthma attacks?
Infections Environmental irritants Cold air Stress Exercise
What is Atopic Asthma?
Immune mediated asthma. Type I hypersensitivity rxn involving IgE bound to mast cells.
What is Non-Atopic Asthma?
We don’t know the cause, but it is presumed to be caused by a hyperreactive bronchial tree
What drug may cause drug-induced asthma? What symptoms might this cause?
Aspirin
Recurrent rhinitis and nasal polyps
Urticaria
What may cause occupational asthma?
Need repeated exposure to the irritating agent
Fumes
Organic chemical dusts
Gases
Describe the pathogenesis of Atopic Asthma
Allergen comes in, gets presented to a T cell. Activate a Th2 cell to produce IL-3, IL-5 (Brings in eosinophils), and IL-4 (to induce B cells to make IgE against the allergen)
When the allergen enters again, mast cells with IgE on surface will degranulate quickly, cause bronchoconstriction, and cause mucus cells to release more mucus
What is status asthmaticus?
Prolonged hyperinflation of the lungs
May appear with mucus casts plugging up the entire bronchial tree
What are Curschmann spirals?
Seen in asthma
Degranulated inflammatory cells and dying epithelial cells covered in mucin
Have a spiral architecture
What are Charcot-Leyden crystals?
They are crystals seen on H&E from the degranulation of eosinophils (bi-lobed nuclei, very pink cytoplasm)
In chronic asthma, what histological changes would you expect to see?
Thickening of the basement membrane
Smooth muscle changes and hypertrophy
Eosinophils present
What are some complications of asthma?
Status asthmaticus Emphysema Chronic bronchitis Pneumonia Bronchiectasis Cor pulmonale