Neuro Things I Can't Remember Flashcards

1
Q

Describe decerebrate posturing

A

Extension of both upper and lower extremities

Damage to the midbrain (red nucleus)

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2
Q

Describe decorticate posturing

A

Damage to the cerebral hemisphere

Arm flexed and leg extended in response to pain

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3
Q

What drugs may be used to slow Alzheimer’s Disease?

A

Central acetylcholinesterase inhibitors (donepezil, rivastigmine, or galantamine)

May add Memantine in later course

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4
Q

What test may be used premortem to diagnosis Alzheimers?

A

Pittsburgh Compound B to bind Beta amyloid

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5
Q

Agnosia occurs when there is damage to…

A

Sensory association cortex

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6
Q

Perivascular Pseudorosettes are seen in what primary brain tumor?

A

Ependymoma

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7
Q

After fixing an aneurysm, the patient may develop cerebral vasospasm in the next few days. How is this minimized (3 Hs)?

A

Hypertension (vasopressors)

Hypervolemia (IV hydration)

Hemodilution (phlebotomy)

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8
Q

When is carotid endarterectomy indicated?

A

Symptomatic atheromatous lesion of 70-99% stenosis at origin of ICA

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9
Q

Cheynes strokes breathing is indicative of what kind of damage to the brain?

A

Bilateral cortical involvement due to metabolic encephalopathy

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10
Q

Two ways to reduce intracranial pressure

A

Hyperventilation and mannitol (osmotic diuretics)

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11
Q

What is the preferred method of determining brain death now?

A

Radioisotope brain scan at the bedside

If there is no cerebral blood flow for 10 minutes, they are braindead

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12
Q

How should essential tremor be treated?

A

Beta blockers or barbiturates

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13
Q

How should choreoathesosis, hemiballismus, and tics be treated?

A

Dopamine antagonist drugs

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14
Q

How should dystonia be treated?

A

Antichoinergics

Benzodiazepines

Botulinum toxin injections

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15
Q

Fibrillary astrocytes are located where?

A

White Matter

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16
Q

Protoplasmic astrocytes are located where?

A

Grey matter

17
Q

Describe satellitosis

A

Oligodendrocytes surrounding a neuron cell body in the CNS

18
Q

Describe cell appearance in Central Chromatolysis

What causes it?

A

Neuron cell body swells and pushes the nucleus to the side

In response to axonal destruction or transection

19
Q

Describe cell appearance in Neuronophagia

What causes it?

A

Neuron is surrounded by microglial cells

Caused by viral encephalitis

20
Q

Describe cell appearance in Acute Neuronal Injury

What causes it?

A

Cell body shrinkage, Red Dead Neurons
Cytoplasm is eosinophilic
Pyknotic nuclei
Loss of Nissl substance

Caused by hypoxia, ischemia, infarct, hypoglycemia

21
Q

Describe cell appearance in Ballooned Neurons

What causes it?

A

Neuronal cell body has swollen, but the nucleus is still in the center of the cell

Seen in neurodegenerative diseases

22
Q

When are Negri bodies seen?

A

Rabies

23
Q

When are Hirano bodies seen? What are they?

A

Alzheimer’s or CJD

Aggregations of alpha-actin

24
Q

When are Lewy bodies seen?

A

Parkinson’s

Dementia with Lewy Bodies

25
Q

Methanol poisoning causes atrophy of the…

A

Putamen

26
Q

CO poisoning causes hemorrhage of the…

A

Glubus pallidus

27
Q

Central Pontine Myelinolysis is caused by…

A

Rapid correction of hyponatremia

28
Q

Multiple System Atrophy

What is the pathology seen? What part of the brain is involved?

A

Parkinsonism
Cerebellar ataxia
Autonomic dysfunction

Expect to see glial cytoplasmic inclusions of alpha synuclein

May see putamen, SN, pons, cerebellum, olive atrophy