Obstructive Airway Diseases Flashcards
1
Q
What is FEV1?
A
Forced expiratory volume of air exiting the lung in first second of breathing
2
Q
What is FVC?
A
Total amount of air expired
3
Q
What is normal FEV1?
A
~3.5-4L
4
Q
What is normal FVC?
A
~5L
5
Q
What is the normal FEV1:FVC ratio
A
0.7-0.8
6
Q
What is normal peak expiratory flow rate?
A
400-600 litres/min
7
Q
What are the causes of chronic bronchitis?
A
smoking, atmospheric pollution, occupation, age and susceptibility
Rarely an alpha-1-antiprotenase deficiency
8
Q
What are the morphological changes in chronic bronchitis?
A
Large airways: mucous gland hyperplasia, goblet cell hyperplasia, inflammation and fibrosis
Small airways: goblet cells appear, inflammation and fibrosis
