OBN: Fetal Development

Question 1

[Lung development]

pseudoglandular stage; growth of intrasegmental bronchial tree

Answer 1

5-17 weeks

Question 2

[Lung development]

chest wall movements detected sonographically

Answer 2

11weeks

Question 3

[Lung development]

canalicular stage; 2nd bronchial cartilage plates extend peripherally

Answer 3

16-25w

Question 4

[Lung development]

canalicular lung development nearly complete

Type II pneumocytes secrete surfactant

Answer 4

24 weeks

Question 5

[Lung development]

terminal sac stage; presence of primitive pulmonary alveoli

Answer 5

> 25 weeks

Question 6

[Amniotic fluid source]

Early pregnancy

Answer 6

Maternal plasma as ultrafiltrate

Question 7

[Amniotic fluid source]

2nd trimester

Answer 7

ECF diffused through fetal skin

Question 8

[Amniotic fluid source]

12 weeks

Answer 8

fetal kidney

Question 9

[Fetotoxic agents]

Renal damage, hypocalvaria

all trimester

Answer 9

ACEi

Question 10

[Fetotoxic agents]

multiple gross anomalies

first trimester

Answer 10

Aminopterin

Question 11

[Fetotoxic agents]

musculinization of female fetus

second and third trimester

Answer 11

androgens

Question 12

[Fetotoxic agents]

neural tube defects

first trimester

Answer 12

Carbamazepine

Question 13

[Fetotoxic agents]

promonged symptomatic neonatal hypoglycemia

all trimesters

Answer 13

Chlorpropamide

Question 14

[Fetotoxic agents]

clear cell vaginal adenoCA; vaginal adenosis

all trimesters

Answer 14

Diethystilbestrol

Question 15

[Fetotoxic agents]

ebstein anomaly

First, third trimester

Answer 15

Lithium

Question 16

[Fetotoxic agents]

mobius sequence

First trimester

Answer 16

Misoprostol

Question 17

[Fetotoxic agents]

major malformation of the face, limbs, other organs

first trimester

Answer 17

Mycophenolate mofetil

Question 18

[Fetotoxic agents]

cutis laxa

first trimester

Answer 18

peniclillamine

Question 19

[Fetotoxic agents]

poor suck reflex and feeding

all trimesters

Answer 19

phencylidine

Question 20

[Fetotoxic agents]

Fetal hydantoin syndrome

all trimesters

Answer 20

phenytoin

Question 21

[Fetotoxic agents]

congenital goiter

all trimesters

Answer 21

PTU

Question 22

[Fetotoxic agents]

Discoloration and defects of teeth and altered bone growth

Answer 22

Tetracycline

Question 23

[Fetotoxic agents]

phocomelia

first trimester

Answer 23

Thalidomide

Question 24

[Fetotoxic agents]

hypoplastic nasal bridge
chondrodysplasia

first trimester

Answer 24

warfarin

Question 25

[Fetotoxic agents] hypoplastic left heart syndrome, micropthalmia/anopthalmia, clefts, ASD

Answer 25

Nitrofurantoin

Question 26

[Fetotoxic agents] gray baby syndrome

Answer 26

chloramphenicol

Question 27

[Fetotoxic agents] nephrotoxicity and ototoxicity in preterm infants

Answer 27

Gentamicin | Streptomycin

Question 28

[Fetotoxic agents] clover leaf skill, wide nasal bridge, low set ears, micrognathia, limb abnormalities

Answer 28

methotrexate

Question 29

[Fetotoxic agents] irreversible hypothyroidism risk of thyroid CA

Answer 29

Radioiodine

Question 30

[Fetotoxic agents] fetal growth and behavioral abnormalities

Answer 30

Lead

Question 31

[Fetotoxic agents] disturbances in neuronal cell division and migration; avoid eating shark, swordfish, king mackerel tilefish, albacore tuna

Answer 31

mercury

Question 32

[Fetotoxic agents] most potent teratogen

Answer 32

retinoids

Question 33

____ mIU/day of retinol causes defects

Answer 33

>10,000 mIU/day

Question 34

[Fetotoxic agents] SSRI that can cause ASD and VSD

Answer 34

Paroxetine

Question 35

[Genetic Abnormality] most common non-lethal trisomy

Answer 35

Down Syndrome Trisomy 21

Question 36

[Genetic Abnormality] strawberry shaped cranium

Answer 36

Edwards Syndrome Trisomy 18

Question 37

[Genetic Abnormality] holoprosencephaly

Answer 37

Patau Syndrome Trisomy 13

Question 38

[Genetic Abnormality] only monosomy compatible with life

Answer 38

Turner 45, XO

Question 39

[Genetic Abnormality] most common sex chromosome abnormality

Answer 39

Klinefelter Syndrome 47, XXY

Question 40

[Genetic Abnormality] microdeletion abnormal laryngeal development "Cat like" cry

Answer 40

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