Endocrine Disorders in Pregnancy Flashcards

1
Q

Increase in TPO antibodies is associated with an increased risk of

A

placenta abruptio

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2
Q

What is the TSH value during the first trimester to diagnose overt hypothyroidism

A

> 10mIU/L

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3
Q

What is the DOC for hypothyroidsm during the first trimester?

A

Levothyroxine

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4
Q

What is the TSH value to diagnose subclinical hypothyroidism?

A

2.5 to 10mIU/L

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5
Q

In pregnant patients with subclinical hypothyroidism and FT4 below 5th percentile, what drug will you give?

A

Levothyroxine

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6
Q

In pregnant patients with TSH 2.5-10mIU/L and normal FT4, what is your next step?

A

Get a TPO antibody

If TPO negative, repeat thyroid function test in 4-8 weels

If TPO positive, start levothyroxine

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7
Q

In pregnant patient with TSH >2.5 with TPO, what is your next step?

A

Begin levothyroxine

Monitor TSH and FT4 every 4 weeks until 20 weeks

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8
Q

In pregnant patients with subclinical thyroidism and on levothyroxine treatment, what is the target TSH in the first trimester?

A

<2.5 mIU/L

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9
Q

In pregnant patients with subclinical thyroidism and on levothyroxine treatment, when will you obtain TSH and FT4?

A

Between 26 to 32 weeks

At 3rd trimester, TSH goal is <3

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10
Q

What are the complications of subclinical hypothyroidism?

A
  1. Miscarriage
  2. Placental abruption
  3. Preterm delovery
  4. Low IQ at age 7-9
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11
Q

What are the complications associated with TPO(+)?

A
  1. spontaneous miscarriage
  2. Recurrent miscarriage
  3. Preterm delivery
  4. Placental abruption
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12
Q

Hyperthyroidism is diagnosed if the TSH is?

A

<0.1 mIU/L

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13
Q

What is the preferred treatment for overt hyperthyroidism in the first trimester?

A

PTU

Methimazole is associated with choanal atresia, aplasia cutis

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14
Q

What is the preferred treatment for overt hyperthyroidism in the 2nd trimester?

A

Methimazole

Due to hepatotoxicity of PTU

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