GYN: Menstrual Cycle Flashcards

1
Q

Hormone that recruits primordial follicle

A

Gonadotropin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The theca lutein cell has ___ receptor and produces ____ hormoine

A

Theca lutein(izing) has LH receptor, produces androstenedione

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

The granulosa cells has ____ receptor and produces ___ hormone

A

Granulosa cell has FSH receptor, produces estorgen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

___ follicle secretes 95% of the estrogen

A

Graafian follicle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Ovulation is caused by the surge of two gonadotropin hormines

A

LH and FSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

LH secretion peaks ___ hours before ovulation

A

10-12 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

____ is the primary leutropic factor maintaining the corpus luteum

A

LH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the three phases of the menstrual cycle?

A
  1. Preovulatory phase / Follicular phase
  2. Ovulation phase
  3. Luteal phase postovulatory phase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

An average menstrual cycle usually lasts for?

A

28days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

FSH stimulates this cell in the pituitary gland

A

Granulosa cell

FGE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

LH stimulates this cell in the pituitary gland

A

Theca Cell

LTT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the hormones secreted by the theca cells?

A
  1. Testosterone

2. Androstenedione

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What hormones are secreted by your granulosa cell?

A
  1. Estrogen
  2. Activin
  3. Inhibin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Inhibin has a positive feed back to what cell?

A

Theca cell

Increasing production of testosterone and androstenedione

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Inhibin has a negative feedback to what hormone?

A

FSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What hormone has a negative feedback to FSH?

A
  1. Estrogen

2. Inhibin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

This hormone has a negative feedback to your theca cells

A

Activin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

The normal, spontaneous, cyclical ovulation occurs at ___ day intervals

A

25 to 35 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

In the menstrual cycle, which days is the narrow window of endometrial receptivity to blastocyst implantation?

A

Days 20-24`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What hormone regulates the secretion of FSH and LH?

A

Gonadotropin-releasing hormone

Released from neurons within the anterior hypothalamis (arcuate nucleus of the basal hypothalamus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

[Pharma]

What is the classic response of GnRH agonist after its initiated?

A
  1. Flare response followed by hypogonadal effect

- relin

22
Q

[Pharma]

GnRH antagonist is a competitive, reversible GnRH receptor antagonist which blocks the release of what hormones?

A
  1. LH
  2. FSH

-relix

23
Q

____ hormone acts on the granulosa cell of the ovarian follicle to stimulate follicular growth

24
Q

___ hormone acts on the theca cells to stimulate ovarian steroid hormone

25
What are the principal sex steroids of the overy?
1. Estradiol 2. Progesterone 3. Androstenedione
26
What hormone regulates the secretion of estrogen?
FSH
27
What are the actions of Estrogen
1. Development of secondary sex characteristics | 2. Thickens endometrium during the proliferative phase
28
What regulates the release of progesterone?
LH
29
What are the actions of progesterone?
1. Maintains endometrium during secretory phase | 2. Prepares EM for implantation
30
Estrogen hormone in menopausal women?
Estrone - E1
31
Estrogen hormone during the reproductive age
Estradiol - E2
32
Estrogen hormone during pregnancy?
Estriol - E3
33
Primary oocyte are formed by what fetal month?
5th fetal month
34
The primary oocytes are arrested in what mitotic phase?
Prophase
35
The first meiotic division of the primary oocyte is completed at ___
Onset of puberty
36
When does secondary oocyte formed?
After completion of Meiosis I the first polar body is released during ovulation
37
The secondary oocyte is arrested in what meiotic phase?
Metaphase II
38
Second meiotic division is completed only when?
During fertilization
39
What is the correct sequence of follicular development?
1. Recruitment of primordial follicle 2. Cohort will grow dominant GC 3. Selection of dominant follicle 4. Dominant follicle increase GC
40
What are the sequence of follicular development?
1. Appearance of LH receptors 2. Granulosa cells - secrete small amount of progesteron, inhibit B inhibit FSH 3. Drop in FSH, follicles wont develop 4. LH stimulates theca cells to produce androstenedione
41
The rise of estrogen is parallel to the growth of ___
dominant follicle
42
Preovulatory follicles increase estrogen secretion _____ before release of ovum with LH surge
34 to 36 hours
43
LH peaks how many hours before ovulation?
10 to 12 hours
44
___ cells produce more progesterone and prostaglandin
Cumulus cell
45
The ability of the granulosa-lutein cells to produce progesterone is due to ____
increased access to steroidogenic precursors
46
In the midluteal phase, there is a secondary rise of estrogen which peaks at _____
0.25mg/day of 17B-estradiol
47
Ovarian progesterone during the midluteal phase peaks at ______ mg/day
25 to 50mg/day
48
[Secretory/proliferative] straight to slightly coiled tubular glands; lined by pseudostratified columnar epithelium
Proliferative Phase
49
What is the first indication of progesterone effects?
Subnuclear vacuolization
50
[Secretory/proliferative] well developed subnuclear vacuoles in all endometrial gland no mitoses in the glands, rising levels of progesterone
secretory
51
What is the primary cause of endometrial ischemia and tissue degeneration?
stasis activation of MMP1 and MMP3 leads to intense vasoconstriction and EM cytokine changes