NT systems iBook

Question 1

location of Ach as NT in peripherhy

Answer 1

NMJ
autonomic preganglionic synapse
parasympathetic post gang fibers
sympathetic post gang fibers that innervate sweat glands/muscle vasodilators
amacrine cells in retina

Question 2

location of Ach in CNS

Answer 2

striatum (motor control)

brainstem arousal system

Question 3

enzyme to make Ach

Answer 3

choline acetyltransferase

Question 4

catabolism of Ach

Answer 4

acetylcholinesterase

1) true or specific choinesteraste on post synaptic cell membrane
2) pseudocholinesterase found in blood and acts on other choline esters

• hydrolyses Ach to acetate and choline
  
  • choline recycled by presynaptic cell uptake, acetate diffuses away

Question 5

what are Ach muscarinic receptors blocked by

Answer 5

atropine

Question 6

ach nicotinc receptors

-fetal vs adult subunits

Answer 6

fetal: 2 a, b, y, sigma
adult: 2 a, b, y, e

-change in subunit structure decreases open time of channel but increases sodium entry (larger conductance)

Question 7

pancreatic beta cells produce and release ___

Answer 7

GABA

Question 8

antibodies to GAD (glutamate decarboxylase) are most common identified in what disease

Answer 8

Type 1 (juvenile) diabetes

Question 9

GABA(B)

Answer 9

coupled to a heterodimer! G protein (Gi and Gq)

Question 10

GABA(C) receptor

Answer 10

found in retina

ionotropic, chloride conductance

Question 11

general anesthetics work primarily at what receptors

Answer 11

extrasynaptic GABA receptors

Question 12

proenkephalins 2 extra subtypes

Answer 12

octapeptide

heptapeptide

Question 13

spinal cord CB-1 receptors

Answer 13

associated with modification of nociceptive inputs

Question 14

neocortical CB-1 receptors

Answer 14

associated with neuroprotection against excitotoxicity

Question 15

hippocampal and basal ganglia CB-1 receptors

Answer 15

associated with changes in affect