Catecholamines iBook Flashcards
what is the RL enzyme in formation of dopamine, norep, and ep
tyrosine hydroxylase
what enzyme is used to convert norep to epin
PNMT
4 major pathways in the brain that utilize dopamine at their NT
1) substantia nigra dopaminergic pathway: motor control, damaged in parkinson’s disease
2) mesolimbic dopaminergic pathway: from ventral tegmental area to nucleus accumbens, pleasure/reward and alteriation assocaited with addiction
3) mesocortical: ventral tegmental area to cortex, attention and higher levels of consciousness
- damage alters cognition/consciousness, dysfunction linked to schizophrenia
4) tuberinfundibular pathway: hypothalamus to anterior pituitary, blocks prolactin release from anterior pituit
what cluster of neurons is norepinephrine found in
and role of norep
loucs ceruleus,
-crutial role in waking us up and awareness
which VMAT is involved in the neuronal vesicular monamine transport
VMAT2
VMAT 1 and 2 are sensitive to what drug
reserpine, reduces the amount of monoamines packaged into the vesicles
-used to treat hypertension
alpha 1 subtype catecholamine receptors
Gq
alpha 2 subtype catecholamine receptor
Gi
B adrenergic receptors are what type of G
Gs
dopamine receptors, D-1 like receptors
D1 and D5
-activate Gs
D2 like receptors
D2,3,4
-activate Gi
which dopamine receptors are found in high concentration in regions of the brain innervated by substantia nigra
D1: movement
D2: inhibition of motion
which dopamine receptor is strongly associated with pleasure/reward system
D3
what 2 enzymes are used to destroy catecholamines
MAO and COMT
what 2 enzymes are required for serotonin syn
trp hydroxylase (RL step) -5-hydroxytrp decarboxylase
